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When taking this medication, you might experience some common side effects such as drowsiness, dizziness, tiredness, dry mouth, nausea, headache, or trouble sleeping. These effects are usually manageable, but if they persist or worsen, it is important to consult a healthcare professional.

There are also some serious side effects that require immediate attention, such as difficulty urinating, a fast or irregular heartbeat, tremors, and changes in mental or mood state, including anxiety, confusion, or restlessness. Additionally, if you experience extreme weakness, these symptoms should be addressed promptly.

In very rare cases, serious side effects like seizures can occur, necessitating urgent medical assistance. Allergic reactions to this medication are uncommon but can be severe. Be vigilant for signs such as rash, itching, swelling of the face, tongue, or throat, severe dizziness, or trouble breathing, and seek immediate medical help if these occur.

While this overview covers the main side effects, there may be others not listed here. If you notice any unusual symptoms, it is advisable to reach out to a healthcare provider for guidance.

It's crucial to avoid using MAO inhibitors, such as isocarboxazid, linezolid, metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, or tranylcypromine, while taking this medication, as it can lead to a severe and potentially life-threatening interaction. Most MAO inhibitors should not be used for at least two weeks before starting this medication. Consult your doctor for guidance on when to begin or discontinue this medication.

Inform your doctor or pharmacist if you're using other products that induce drowsiness, such as opioid pain or cough medications like codeine or hydrocodone, alcohol, marijuana, sleep or anxiety drugs like alprazolam, lorazepam, or zolpidem, muscle relaxants like carisoprodol or cyclobenzaprine, or other antihistamines such as chlorpheniramine or diphenhydramine.

Check the labels of all your medications, including those for allergies or cough and cold, as they may contain ingredients that cause drowsiness or similar components, like decongestants such as phenylephrine. Consult your pharmacist to ensure safe use of these products.

Avoid using any topical antihistamines, like diphenhydramine cream, ointment, or spray, alongside this medication, as this may heighten side effects.

Since cetirizine is very similar to hydroxyzine and levocetirizine, do not use these medications in conjunction with cetirizine.

This medication might interfere with certain laboratory tests, such as allergy skin tests, potentially leading to inaccurate results. Ensure that all healthcare providers and lab personnel are aware of your medication use.