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Lurasidone, marketed as Latuda, is used to treat certain mental health disorders, including schizophrenia and depression associated with bipolar disorder. While it offers therapeutic benefits, it also comes with important safety considerations and potential risks that need careful attention. Below are key safety and warning details for those considering or currently taking Latuda:

• Increased Risk in Older Adults with Dementia-Related Psychosis: Older adults (65+) with dementia-related psychosis should avoid Latuda, as it can lead to a higher risk of serious side effects, such as strokes or heart problems, which could be fatal. Discuss alternative treatments with your healthcare provider if dementia-related symptoms are present.

• Worsening Depression and Suicidal Thoughts: Latuda may exacerbate depression and lead to suicidal thoughts, particularly in individuals under 25, during the initial treatment period or when the dose is adjusted. Immediate medical attention is advised if any unusual behavioral changes occur.

• Neuroleptic Malignant Syndrome: This is a rare but life-threatening condition that can manifest as fever, muscle stiffness, confusion, or irregular heartbeat. Seek urgent medical care if these symptoms appear.

• Tardive Dyskinesia: Long-term use of Latuda can result in involuntary muscle movements, which may become permanent. Higher-risk groups include older adults and women over 65. Consult your provider if you experience uncontrolled movements.

• Metabolic Changes: Latuda can affect weight, blood sugar, and cholesterol levels. Regular monitoring and maintaining a healthy lifestyle are recommended to manage these side effects.

• Elevated Prolactin Levels: Increased prolactin can cause symptoms like nipple discharge or menstrual irregularities. Report these symptoms to your healthcare provider.

• Blood Pressure and Balance Issues: Latuda may lower blood pressure, leading to dizziness or falls. Caution is advised when changing positions from sitting to standing.

• Risk of Infection: A decrease in white blood cells can increase infection risk. Regular blood tests may be necessary to monitor your blood cell counts.

• Drowsiness and Concentration Problems: Latuda can cause significant drowsiness, impacting focus and reaction time. Avoid driving or operating machinery until you understand how Latuda affects you.

• Seizure Risk: Individuals with a history of seizures should inform their healthcare provider before starting Latuda, as it may increase seizure risk.

• Manic Episodes in Bipolar Disorder: Latuda can trigger manic episodes in patients with bipolar disorder. Report any behavioral changes to your provider.

• Sensitivity in Parkinson's and Lewy Body Dementia: Those with these conditions may be more sensitive to Latuda, experiencing symptoms such as confusion and movement issues. Immediate medical evaluation is recommended if these occur.

• Drug Interactions: Avoid using Latuda with certain medications such as ritonavir, phenytoin, carbamazepine, rifampin, and St. John's wort due to potential interactions. Always discuss your medications with your healthcare provider to prevent adverse effects.

In case of an overdose, seek emergency medical assistance promptly. Always consult your healthcare provider to understand the full scope of potential risks and benefits before starting Latuda.

Common side effects:

• Drowsiness
• Nausea
• Dizziness
• Inability to keep still
• Weight gain
• Lightheadedness
• Feeling shaky

Less common but important to monitor:

• Stomach discomfort
• Diarrhea
• Vomiting
• Decreased appetite
• Blurry vision
• Rashes
• Itching
• Elevated blood pressure
• Elevated heart rate
• Difficulty sleeping
• Infections

Serious side effects:

• Neuroleptic malignant syndrome
• Risk of stroke
• Suicidal thoughts
• Seizures
• Trouble swallowing
• Painful or prolonged erections
• Increased blood sugar
• Elevated cholesterol levels
• Increased prolactin levels
• Allergic reaction

Interactions with high risk of serious adverse effects and should be avoided:

• Boceprevir
• Bromopride
• Carbamazepine
• Clarithromycin
• Cobicistat
• Conivaptan
• Darunavir
• Enzalutamide
• Fosphenytoin
• Idelalisib
• Indinavir
• Itraconazole
• Ketoconazole
• Lopinavir
• Metoclopramide
• Nefazodone
• Nelfinavir
• Phenytoin
• Posaconazole
• Primidone
• Rifabutin
• Rifampin
• Rifapentine
• Ritonavir
• Saquinavir
• St John's Wort
• Telaprevir
• Telithromycin
• Tipranavir
• Voriconazole

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Abiraterone Acetate
• Amprenavir
• Aprepitant
• Atazanavir
• Buprenorphine
• Ceritinib
• Ciprofloxacin
• Crizotinib
• Delavirdine
• Diltiazem
• Duvelisib
• Erythromycin
• Fluconazole
• Fosamprenavir
• Fosaprepitant
• Fosnetupitant
• Imatinib
• Ivosidenib
• Larotrectinib
• Lefamulin
• Letermovir
• Lorlatinib
• Lumacaftor
• Methadone
• Netupitant
• Remifentanil
• Verapamil