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When using this medication, you might experience mild side effects such as eye discomfort, redness, burning, blurred vision, upset stomach, dizziness, or drowsiness. In some cases, you may also notice eye itching, watering, or eyelid swelling, which could indicate an allergic reaction of the eye. Although these side effects are generally not severe, if they persist or worsen, it’s important to inform your healthcare provider.

While serious side effects are uncommon, it’s crucial to be vigilant. Contact your healthcare provider immediately if you encounter symptoms such as fainting, changes in mental state like depression, or irregular heartbeat. Severe allergic reactions to this medication are rare, but they require urgent medical attention. Symptoms of a serious allergic reaction can include a rash, swelling particularly of the face, tongue, or throat, severe dizziness, and difficulty breathing.

Remember that while many individuals using this medication do not experience significant side effects, it is essential to report any unexpected or severe reactions to your healthcare provider promptly. This ensures your safety and helps manage any potential risks associated with the medication.

When using this medication, be aware that combining it with MAO inhibitors can lead to a severe, potentially life-threatening reaction. MAO inhibitors to avoid include isocarboxazid, Linezolid, Metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, Rasagiline, safinamide, Selegiline, and Tranylcypromine. These should not be taken during treatment and generally not for two weeks prior. Consult your doctor on when to begin or discontinue the medication.

Additionally, inform your healthcare provider if you are using any substances that may cause drowsiness, such as alcohol, cannabis, antihistamines like Cetirizine and diphenhydramine, sleep or anxiety medications such as Alprazolam, Diazepam, and Zolpidem, muscle relaxants, or opioid pain medications like codeine. Always check the labels of other medicines, including those for coughs and colds, for ingredients that can cause drowsiness and consult your pharmacist on safe usage.

For those using Iopidine (apraclonidine), it is important to disclose all medications and supplements you are taking to your doctor and pharmacist. While the full list of interactions is not detailed here, one known interaction is with Iobenguane I 131. If these are used together, your doctor may need to adjust dosages or frequency of use.