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This medication carries several important safety warnings and contraindications that you should be aware of before use. Please review the following information carefully and discuss any concerns with your healthcare provider:

• Increased Uric Acid Levels: Use of Nexlizet (bempedoic acid / ezetimibe) may result in elevated uric acid levels in the blood, potentially leading to gout symptoms such as joint pain, redness, and tenderness. These effects could occur within the first month of treatment. If you notice any signs of gout, contact your healthcare provider. You may need a blood test to check uric acid levels and possibly start treatment to lower them, especially if you have a history of gout.

• Tendon Rupture or Injury: Although uncommon, there is a potential risk for tendon injuries or ruptures while using Nexlizet. Incidents have been reported in the shoulder, biceps, or Achilles tendon, typically occurring within weeks to months of starting treatment. The risk factors include being over 60 years of age, concurrent use of corticosteroids or certain antibiotics, kidney failure, and a history of tendon issues.

• Contraindications: This medication should not be used if you have any known allergies to ezetimibe or bempedoic acid. If you have such allergies, consult your healthcare provider prior to starting this medication to avoid serious health risks.

Ensure to communicate with your healthcare provider about any pre-existing conditions, medications you are currently taking, or any other health concerns to safely use this medication.

When taking this medication, you may experience some common side effects such as a runny or stuffy nose, abdominal pain, constipation, high uric acid levels, kidney issues, anemia, elevated liver enzymes, muscle spasms, upper respiratory infections, or diarrhea. These side effects are generally mild but consult a healthcare professional if they persist or worsen.

There are other side effects that have been reported, including gout, gallstones, back or stomach pain, joint pain, sinus infections, and fatigue. While these are less common, you should inform your healthcare provider if they occur, especially if they become severe.

It is important to be aware of more serious side effects, although they are rare. These include allergic reactions characterized by skin rash, itching, hives, or swelling of the face, lips, tongue, or throat. Additionally, you should seek immediate medical attention if you experience severe toe or joint pain, difficulty urinating, or any signs of tendon damage such as joint, muscle, or tendon pain and swelling. This is particularly important if you are over 60, taking corticosteroids or fluoroquinolones, or have existing kidney or tendon issues.

In case of a very serious allergic reaction, immediate medical assistance is crucial. Symptoms may include rash, itching or swelling, severe dizziness, and trouble breathing. Always consult your healthcare provider if you notice any other side effects not mentioned here.