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This document outlines critical safety information about the use of Orphengesic Forte. It is essential to understand the potential risks and necessary precautions. If you have any concerns, please consult your healthcare provider.

• Gastrointestinal Risks: Orphengesic Forte may cause irritation in the stomach or intestines, leading to symptoms like stomach pain or heartburn. In severe cases, it can result in swelling, bleeding, and ulcers. The likelihood of bleeding increases if you are concurrently using blood thinners such as warfarin or oral corticosteroids. Immediate medical attention is necessary if you experience persistent stomach pain, vomit blood or material resembling coffee grounds, or have bloody or tarry stools. Risks are heightened in individuals with a history of stomach bleeding or ulcers, bleeding disorders, concurrent use of other NSAIDs, blood thinners, or corticosteroids, alcohol users, those aged 60 or older, long-term users of the medication, or those taking doses higher than recommended.

• Risks During Pregnancy: If you are 20 weeks or more into your pregnancy, Orphengesic Forte could harm your unborn child by affecting kidney function and amniotic fluid levels. After 30 weeks of pregnancy, there is a risk of heart defects in the fetus. Discuss safer alternatives with your healthcare provider if you are pregnant.

• Severe Allergic or Skin Reactions: Though infrequent, severe allergic or skin reactions can occur, presenting as fever, facial swelling, skin reddening or peeling, painful rash, or fluid-filled blisters. If you notice any of these symptoms, discontinue use immediately and seek emergency medical care.

• Contraindications: Do not use Orphengesic Forte if you have the following conditions, as it may pose serious health risks:

  • Glaucoma
  • Blockage in the stomach, intestines, or other parts of the digestive tract
  • Enlarged prostate or bladder problems
  • Myasthenia gravis
  • Severe allergic reaction to aspirin or other NSAIDs
  • Caffeine sensitivity

This information is crucial for ensuring the safe use of Orphengesic Forte. Always consult your healthcare provider for personalized advice and guidance.

When taking this medication, you might experience some mild side effects such as dry mouth, dizziness, drowsiness, lightheadedness, blurred vision, upset stomach, heartburn, nausea, vomiting, constipation, and trouble sleeping. These effects are generally not severe and can often be managed by simple measures like staying hydrated or using sugarless gum for dry mouth. However, if these symptoms persist or worsen, it's important to consult with a healthcare professional.

There are also more significant side effects that require attention if they occur. These include mental or mood changes like confusion, anxiety, and hallucinations, as well as physical symptoms such as tremors, a racing or irregular heartbeat, hearing changes, difficulty urinating, unusual bleeding or bruising, fainting, eye pain, and extreme fatigue. Additionally, symptoms like yellowing of the eyes or skin, dark urine, and changes in urination could indicate kidney issues.

A rare but serious risk associated with this medication is stomach or intestinal bleeding, which may present as persistent stomach pain, black stools, or vomit that resembles coffee grounds. If these symptoms occur, seek medical attention immediately. Moreover, although rare, severe allergic reactions can happen, characterized by fever, swollen lymph nodes, a rash, intense itching or swelling, severe dizziness, and trouble breathing. Immediate medical care is crucial if you experience any of these symptoms.

Always be vigilant for any other unusual symptoms and communicate with a healthcare provider for guidance. Remember, while many individuals use this medication without significant issues, awareness of potential side effects ensures better health management.

This medication can interact with several other products, including dichlorphenamide, methotrexate, mifepristone, and vemurafenib. It may increase the risk of bleeding if used with drugs that also cause bleeding, such as anti-platelet medications like clopidogrel, and blood thinners such as dabigatran, enoxaparin, or warfarin.

Be sure to read the labels on all your medications, both prescription and non-prescription, as many contain pain relievers or fever reducers like aspirin or NSAIDs (e.g., ibuprofen, ketorolac, naproxen), which are similar to this medication and may heighten the risk of side effects when used together. Consult your doctor or pharmacist for further advice.

Inform your healthcare provider if you are taking other substances that cause drowsiness, including opioid pain relievers (e.g., codeine, hydrocodone), alcohol, marijuana (cannabis), sleep or anxiety medications (e.g., alprazolam, lorazepam, zolpidem), muscle relaxants (e.g., carisoprodol, cyclobenzaprine), or antihistamines (e.g., cetirizine, diphenhydramine). Check the labels of your allergy or cough-and-cold products as they may contain drowsiness-inducing ingredients. Consult your pharmacist for safe usage advice.

Additionally, this medication may affect certain lab tests, like dipyridamole-thallium imaging tests or some urine tests, potentially leading to inaccurate results. Ensure all your healthcare providers and lab personnel are aware that you are taking this drug.