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The following safety information is essential for understanding the potential risks and necessary precautions when using this medication. Please read carefully and consult your healthcare provider with any questions or concerns.

• Serotonin Syndrome: This potentially life-threatening condition occurs when there is an excess of serotonin in the brain. It is more likely if cyclobenzaprine is taken with medications that increase serotonin, such as specific antidepressants, migraine, and pain medications. Symptoms include rapid heartbeat, sweating, muscle stiffness, fever, and confusion. If you experience these symptoms, seek medical attention immediately. Ensure your healthcare provider is informed of all medications you are taking to prevent dangerous interactions.

• Impaired Alertness: Cyclobenzaprine can cause drowsiness and impact concentration, particularly in individuals over 65 or those taking other sedative medications. Avoid alcohol consumption, as it can exacerbate these effects. Refrain from driving or operating heavy machinery until you understand how the medication affects you.

• Dryness of Mouth, Eyes, and Urinary Issues: Cyclobenzaprine may reduce bodily fluids, causing dry mouth, dry eyes, or difficulty urinating. Individuals with glaucoma, high eye pressure, or urinary issues may experience worsened symptoms. Inform your healthcare provider of any such conditions or if you are taking anticholinergic medications, which may increase these side effects.

• Liver Impairment Caution: Those with liver conditions should use cyclobenzaprine cautiously, and it is not recommended for individuals with severe liver problems. The liver processes this medication, so impaired liver function can lead to increased side effects like drowsiness and dizziness. Discuss your medical history with your provider to ensure safe use.

• Contraindications: Cyclobenzaprine should not be used if you are currently taking a monoamine oxidase inhibitor (MAOI) or have done so within the last 14 days. It is also contraindicated for individuals who have recently experienced a heart attack, have specific heart conditions (such as abnormal rhythms, heart block, or heart failure), or have hyperthyroidism. Consult with your healthcare provider if any of these conditions apply to you.

When taking this medication, some common side effects you might experience include drowsiness, dry mouth, dizziness, and feeling tired. These effects are generally mild and often resolve on their own, but if they persist or worsen, it’s advisable to consult your healthcare provider. Headaches can also occur, though less frequently.

In some cases, other side effects such as indigestion, nausea, constipation, and additional drowsiness may be noted. These symptoms are also typically mild but should be monitored. If any of these become concerning, reaching out to a healthcare professional is recommended for advice.

On rare occasions, more severe side effects might occur, which require immediate medical attention. These include fast or irregular heartbeat, mental or mood changes like confusion or hallucinations, diarrhea, blurry vision, irritability, nervousness, and weakness. Additionally, a serious allergic reaction is possible but rare. Watch for symptoms like rash, itching or swelling of the face, tongue, or throat, severe dizziness, and trouble breathing. If any of these severe symptoms develop, seek urgent care swiftly.

This medication can interact with several other drugs. Specifically, tricyclic antidepressants like Amitriptyline and imipramine might interact with it. Additionally, combining this medication with MAO inhibitors could lead to a severe, potentially life-threatening reaction. Therefore, avoid using MAO inhibitors such as isocarboxazid, Linezolid, Metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, Rasagiline, safinamide, Selegiline, and Tranylcypromine during treatment. Most MAO inhibitors should also not be used for at least two weeks before starting this medication. Consult your doctor for guidance on when to begin or discontinue use.

Before you start using this drug, inform your healthcare provider if you are taking any substances that increase serotonin levels, including certain street drugs like MDMA ("ecstasy"), St. John's wort, or antidepressants such as SSRIs (e.g., Fluoxetine, paroxetine) and SNRIs (e.g., Duloxetine, Venlafaxine), as well as Tramadol.

It is also important to inform your doctor or pharmacist if you are consuming other products that may cause drowsiness, including opioid painkillers or cough suppressants (e.g., codeine, hydrocodone), alcohol, marijuana (cannabis), sleep aids or anxiety medications (e.g., Alprazolam, Lorazepam, Zolpidem), other muscle relaxants (e.g., Carisoprodol, Methocarbamol), or antihistamines (e.g., Cetirizine, diphenhydramine).

Be sure to check the labels of any other medications you are taking, such as allergy or cold remedies, as they could contain ingredients that induce drowsiness. Consult with your pharmacist to ensure safe usage of these products.