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The following information outlines important safety warnings and precautions associated with the use of this medication. Please read carefully and discuss any concerns with your healthcare provider.

• Increased Bleeding Risk: Use of pentoxifylline ER alongside nonsteroidal anti-inflammatory drugs (NSAIDs) like aspirin, anticoagulants such as warfarin (Coumadin), or platelet-affecting medications like clopidogrel (Plavix) heightens bleeding risk. Some individuals have experienced bleeding without concurrent use of other blood-thinning agents. Be vigilant for signs of bleeding, including blood in urine, blood in stool, or unexplained bruising, and contact your healthcare provider immediately if these occur. You may require more frequent monitoring for bleeding complications, particularly if you have recently undergone surgery, are using blood thinners, or have had a recent stomach ulcer.

• Drug Interactions: Pentoxifylline ER may interact with other medications, altering their levels in your body or its own. For instance, concurrent use with theophylline can increase theophylline levels, potentially causing side effects. Similarly, medications like ciprofloxacin (Cipro) can elevate pentoxifylline ER levels. It is crucial to inform your healthcare provider of all medications you are currently taking before beginning treatment with pentoxifylline ER.

• Contraindications: Certain conditions or factors may render the use of this medication unsafe. If you have had a recent cerebral or retinal hemorrhage (bleeding in the brain or eyes) or a history of adverse reactions to caffeine, theophylline, or theobromine, consult your healthcare provider before initiating treatment with this medication.

Follow these guidelines carefully to mitigate potential risks and ensure safe use of the medication.

Common side effects:

• Indigestion
• Nausea
• Dizziness
• Vomiting
• Headaches

Less common but important to monitor:

• Chest pain
• Burping
• Bloating
• Gas
• Shakiness (tremor)
• Shortness of breath
• Swelling
• Low blood pressure
• Reduced appetite
• Constipation
• Dry mouth
• Blurry vision

Serious side effects:

• Bleeding

When taking pentoxifylline, it's important to be aware of potential interactions with other medications:

• Blood Thinners and Antiplatelet Agents: Combining pentoxifylline with anticoagulants (like Warfarin) or antiplatelet drugs (such as Aspirin) may increase the risk of bleeding. Regular monitoring of blood clotting times is recommended when these medications are used together.

• Nonsteroidal Anti-Inflammatory Drugs (NSAIDs): Using NSAIDs alongside pentoxifylline can also elevate bleeding risk. Caution is advised when combining these drugs.

• Theophylline: Pentoxifylline may raise the levels of theophylline in the blood, potentially leading to toxicity. Monitoring theophylline levels is advisable if both medications are prescribed concurrently.

• Cimetidine: This medication can increase pentoxifylline concentrations in the bloodstream, which might heighten the likelihood of side effects. Close observation is recommended when these drugs are taken together.

• Antihypertensive Medications: Pentoxifylline may enhance the blood pressure-lowering effects of these drugs, possibly causing low blood pressure. Regular blood pressure checks are suggested, and dosage adjustments may be necessary.

• Antidiabetic Medications: Pentoxifylline might amplify the effects of insulin or oral diabetes medications, increasing the risk of low blood sugar. Monitoring blood sugar levels is important when using these medications together.

Always inform your healthcare provider about all medications and supplements you're taking to ensure safe and effective use of pentoxifylline.