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You might experience some mild side effects such as drowsiness, dizziness, flushing, headache, nausea, nervousness, blurred vision, or a dry mouth, nose, or throat. These are generally not serious, but if they persist or worsen, it's important to speak with your healthcare provider. To help manage dizziness and lightheadedness, rise slowly from sitting or lying down. For dry mouth, try sugarless hard candy, ice chips, sugarless gum, drinking water, or using a saliva substitute.

While most people do not experience serious effects, be alert for any mental or mood changes like hallucinations or confusion, shaking, trouble urinating, or weakness, and inform your healthcare provider promptly if they occur. In rare cases, serious side effects such as a fast, slow, or irregular heartbeat, or seizures may happen. If you encounter these, seek medical attention immediately.

Additionally, though extremely rare, severe allergic reactions can occur. Symptoms include rash, itching, swelling (especially of the face, tongue, or throat), severe dizziness, and difficulty breathing. If you experience any of these, urgent medical help is necessary. This overview does not cover all possible side effects, so if you notice anything unusual, reach out to your healthcare provider for further advice.

Certain products may interact with this medication, including skin-applied antihistamines like diphenhydramine cream, ointment, or spray. Combining this drug with MAO inhibitors can lead to a dangerous, potentially fatal reaction. Avoid using MAO inhibitors (such as isocarboxazid, Linezolid, Metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, Rasagiline, safinamide, Selegiline, Tranylcypromine) while taking this medication. Generally, MAO inhibitors should not be used for two weeks prior to starting this medication. Consult your doctor about the appropriate timing for starting or stopping these medications.

This medication contains ingredients found in various prescription and over-the-counter products. Carefully check all your medication labels to ensure you are not taking multiple products with the same ingredients. If you are unsure about any ingredients, ask your pharmacist for clarification.

Inform your doctor or pharmacist if you are using other products that can cause drowsiness, such as opioid pain or cough relievers (e.g., codeine, hydrocodone), alcohol, cannabis, sleep or anxiety medications (e.g., Alprazolam, Lorazepam, Zolpidem), muscle relaxants (e.g., Carisoprodol, Cyclobenzaprine), or other antihistamines (e.g., Cetirizine, diphenhydramine). Check all your medications, including those for allergies or cold and cough, as they may contain drowsiness-inducing ingredients. Consult your pharmacist about how to safely use these products.

This medication may affect certain lab tests, like allergy skin tests, potentially leading to incorrect results. Ensure all healthcare providers and lab personnel are aware that you are taking this medication.