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Ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID), is associated with certain risks and precautions. It is important to be aware of these to use the medication safely:

• Cardiovascular Risks: There is a rare possibility that ibuprofen could increase the risk of a heart attack or stroke. This risk can arise at any point during the use of the medication but is higher if used for an extended period. The likelihood is also greater in older adults or individuals with heart disease or risk factors for heart disease, such as smoking, family history, high blood pressure, or diabetes. Avoid using ibuprofen immediately before or after heart bypass surgery (CABG).

• Gastrointestinal Risks: Ibuprofen may infrequently cause serious, potentially fatal bleeding in the stomach or intestines. This can occur without any warning signs and may be more prevalent among older adults.

• Signs of Serious Side Effects: Discontinue the use of ibuprofen and seek immediate medical attention if you experience any of the following: persistent stomach or abdominal pain, black or tarry stools, vomit resembling coffee grounds, chest, jaw, or left arm pain, shortness of breath, unusual sweating, confusion, weakness on one side of the body, difficulty speaking, or sudden changes in vision.

• Consultation with Healthcare Provider: It is crucial to discuss with your doctor or pharmacist the benefits and potential risks associated with ibuprofen to determine if it is suitable for you.

Following these guidelines will help ensure safe use of ibuprofen while minimizing the risk of adverse effects.

When taking this medication, you might experience mild side effects such as an upset stomach, nausea, vomiting, headache, diarrhea, constipation, dizziness, or drowsiness. These symptoms are usually temporary, but if they persist or worsen, it is important to consult a healthcare professional. It's also important to monitor your blood pressure regularly, as this medication can potentially increase it.

Be vigilant for more serious side effects, which require immediate medical attention. These include easy bruising or bleeding, changes in hearing like ringing in the ears, mental or mood changes, an unexplained stiff neck, signs of kidney issues such as changes in urine output, vision changes, or symptoms of heart failure, including swollen ankles or feet, unusual tiredness, or sudden weight gain. In rare instances, the medication can cause severe liver disease. If you experience persistent nausea or vomiting, loss of appetite, dark urine, abdominal pain, or yellowing of the skin or eyes, seek urgent medical help.

Allergic reactions are very rare but can be serious. If you develop a fever, swollen lymph nodes, rash, itching or swelling especially around the face, tongue, or throat, severe dizziness, or breathing difficulties, contact emergency services immediately. Always communicate any unlisted side effects to your healthcare provider for further guidance.

Some medications that can interact with this drug include aliskiren, ACE inhibitors (like captopril and lisinopril), angiotensin II receptor blockers (such as valsartan and losartan), cidofovir, corticosteroids (such as prednisone), lithium, and diuretics (such as furosemide). This drug may also raise the risk of bleeding if taken with other medications that cause bleeding, such as anti-platelet drugs like clopidogrel and blood thinners including dabigatran, enoxaparin, and warfarin.

It's important to carefully read the labels of all prescription and over-the-counter medications, as many contain pain relievers or fever reducers like aspirin and NSAIDs (such as celecoxib, ketorolac, or naproxen), which are similar to ibuprofen and could increase the risk of side effects if used together. If your doctor has advised you to take low-dose aspirin (usually 81-162 milligrams daily) to prevent heart attack or stroke, continue to do so unless instructed otherwise by your doctor. Regular use of ibuprofen might reduce aspirin's effectiveness in preventing heart attacks or strokes. Discuss with your doctor about using another medication, like acetaminophen, for pain or fever. If ibuprofen use is necessary, consult your doctor about the timing with immediate-release aspirin (not enteric-coated). Take ibuprofen at least 8 hours before or 2 hours after your aspirin dose. Do not alter your aspirin dosage or method of taking it without your doctor's guidance.