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It is important to be aware of the potential risks and precautions associated with the use of this medication. Review the following safety information carefully and discuss any concerns with your healthcare provider.

• Vision Changes: Trihexyphenidyl may increase eye pressure, posing a risk for individuals with narrow-angle glaucoma, potentially leading to blindness. If you experience blurry vision, contact your healthcare provider immediately.

• Risk of Heat Stroke: This medication can impair your body's ability to sweat, increasing the risk of heat stroke, particularly during hot weather or while engaging in outdoor manual labor. Stay well-hydrated and avoid excessive heat exposure. Alcohol consumption may exacerbate this risk.

• Neuroleptic Malignant Syndrome (NMS): Abrupt discontinuation or rapid dose reduction of trihexyphenidyl can lead to NMS, a serious condition characterized by muscle stiffness, sweating, fever, rapid heart rate, and irregular pulse. Seek immediate medical attention if these symptoms occur.

• Use in Older Adults: Older adults may be more susceptible to the anticholinergic side effects of trihexyphenidyl, such as blurred vision and dizziness, which can increase the risk of falls. Regular monitoring by your healthcare provider is essential, especially if side effects worsen over time.

• Contraindications: Avoid using trihexyphenidyl if you have narrow-angle glaucoma, as it may pose significant health risks.

In case of overdose, seek emergency medical assistance promptly. Always adhere to your healthcare provider's instructions regarding the use of this medication and inform them of any pre-existing health conditions or ongoing treatments to prevent adverse interactions.

Common side effects:

• drowsiness
• dizziness
• constipation
• nausea
• blurred vision
• dry mouth
• nervousness

Less common but important to monitor:

• headaches
• memory issues
• hallucinations
• erratic behavior

Serious side effects:

• severe stomach pain
• painful swallowing
• difficulty urinating
• muscle weakness
• chest pain
• severe dizziness
• irregular heartbeat
• mental changes
• vision problems
• rash
• itching
• swelling
• trouble breathing
• neuroleptic malignant syndrome

Interactions with high risk of serious adverse effects and should be avoided:

• pramlintide

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• corticosteroids (such as prednisone)
• potassium tablets/capsules
• opioid pain relievers (such as codeine, hydrocodone)
• medications for sleep or anxiety (such as alprazolam, lorazepam, zolpidem)
• muscle relaxants (such as carisoprodol, cyclobenzaprine)
• antihistamines (such as cetirizine, diphenhydramine)

Interactions with low risk that usually do not require a change in therapy:

• alcohol
• marijuana (cannabis)