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You may experience nausea, vomiting, diarrhea, loss of appetite, mouth sores, a black hairy tongue, sore throat, dizziness, headache, or rectal discomfort. These are common side effects and typically resolve on their own, but inform your healthcare provider if they persist or worsen. Most people taking this medication do not experience serious side effects, but it's important to be aware of them.

Contact your healthcare provider immediately if you notice severe side effects such as nail discoloration, muscle pain, difficulty swallowing, signs of kidney issues like changes in urine output, tooth discoloration, numbness or tingling in your hands or feet, unusual fatigue, persistent sore throat, fever, chills, changes in hearing, easy bruising or bleeding, or signs of liver problems, such as abdominal pain, yellowing of the skin or eyes, and dark urine.

Rarely, this medication can increase pressure around the brain, especially in overweight women of childbearing age. If you experience severe or persistent headaches, nausea, or vision changes, seek medical attention immediately, as this could lead to permanent vision loss. Additionally, a severe intestinal condition caused by C. difficile bacteria may occur, even weeks after treatment. Watch for persistent diarrhea, abdominal pain, or blood in stools and avoid anti-diarrhea medications unless advised by your doctor.

Long-term use may result in oral thrush or yeast infections. If you notice white patches in your mouth or changes in vaginal discharge, consult your doctor. Although rare, serious allergic reactions can occur. Seek emergency help if you experience rash, itching, severe dizziness, swelling, difficulty breathing, joint pain, chest pain, or irregular heartbeat. Always consult your doctor if you have side effects not listed here.