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This medication is administered exclusively by injection under the skin. It is crucial not to inject it into a vein or muscle, as this may result in severe harm or even death due to blockage, dangerous blood clots, or local injury. Here are critical safety warnings and usage instructions for this medication:

• Injection Precaution: This medication must strictly be given subcutaneously (under the skin). Intravenous or intramuscular injections are highly dangerous and can lead to serious harm, including death.

• Risk of Addiction and Misuse: This medication is a controlled substance with potential for addiction and misuse. Use only as prescribed by your healthcare provider.

• Respiratory Depression: This medication can cause dangerously slow breathing, which may be life-threatening. The risk is heightened if you are taking other medications that depress the respiratory system, consuming alcohol, or have existing breathing issues such as COPD or asthma.

• Newborn Harm: Pregnant individuals using this medication can pass it to their unborn child, potentially leading to opioid dependence and withdrawal symptoms in newborns. Inform your healthcare provider if you are pregnant to ensure appropriate care for your baby.

• Adrenal Hormone Levels: Long-term use of this medication can lead to decreased adrenal hormone levels. Symptoms include nausea, vomiting, loss of appetite, fatigue, dizziness, and weakness. Contact your provider if you experience these symptoms.

• Withdrawal Symptoms: Abruptly stopping this medication may lead to withdrawal symptoms. Always consult your healthcare provider before discontinuing use.

• Liver Health: This medication can cause liver damage. It is not recommended for individuals with pre-existing liver conditions. Your doctor may monitor your liver function regularly through blood tests.

• Pain Management: Inform your provider if you need additional pain management while on this medication. Non-opioid pain relievers are preferred to avoid complications.

• Opioid Naïve Individuals: This medication is intended only for individuals who are already using opioids. It is not suitable for those who have never taken opioids before, as it could be fatal.

• Heart Rhythm Issues (QT Prolongation): This medication can cause serious heart rhythm problems. Inform your provider of any heart issues or medications you are taking that affect heart rhythm. Seek emergency help if you experience symptoms like chest pain, fainting, or difficulty breathing.

• Allergies: Do not use if you have an allergy to buprenorphine or the Atrigel delivery system.

For any signs of an opioid overdose, it is recommended to have naloxone available and educate family members on its use. If you have any concerns or questions, consult your healthcare provider for more information.

When using this medication, you might experience some common side effects such as nausea, vomiting, headache, constipation, and reactions at the injection site like pain, itching, or redness. These effects are typically mild and often manageable. To help alleviate constipation, consider increasing your dietary fiber intake, staying hydrated, and engaging in regular exercise. If these symptoms persist or worsen, consult your healthcare provider.

Drowsiness, dizziness, and fatigue can also occur, so it's advisable to rise slowly from sitting or lying positions to prevent lightheadedness. Although many users do not experience severe side effects, it's crucial to be aware of them. Serious side effects that require immediate medical attention include dangerously slow breathing, possibly leading to bluish lips or extremities, and severe allergic reactions characterized by rash, swelling, or difficulty breathing.

In rare instances, this medication can lead to serious conditions such as liver damage or heart rhythm problems, which present symptoms like abdominal pain, yellowing of the skin or eyes, and irregular heartbeats. It might also induce opioid withdrawal symptoms, especially in those transitioning from long-acting opioids, with signs like anxiety, irritability, and trouble sleeping. If you notice symptoms of serious injection site reactions or any unusual changes in mood or mental state, it's important to seek medical help promptly.