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Buprenorphine-naloxone

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generic Suboxone, Zubsolv, Bunavail

This medication is a combination of two active ingredients, buprenorphine and naloxone, used for the treatment of opioid use disorder (OUD) in adults. Buprenorphine is classified as a mixed opioid agonist-antagonist, which helps alleviate withdrawal symptoms when discontinuing opioid use. Naloxone is an opioid antagonist that blocks the effects of opioids and is included to prevent misuse through injection, as it can cause severe withdrawal if injected. When taken orally or dissolved under the tongue, naloxone has minimal effect. This treatment is part of a comprehensive program, which includes counseling and support to aid recovery. The medication is administered sublingually, meaning it is placed under the tongue to dissolve once daily. Individual dosages may vary. Suboxone, the brand name for this medication, has been discontinued in its original form, but generic alternatives are available under names such as Zubsolv. Potential side effects include headache, pain, and nausea. Due to the risk of addiction and misuse, this medication is classified as a controlled substance. Consult your healthcare provider regarding the necessity of having additional naloxone to treat potential opioid overdoses, and educate those around you about overdose signs and emergency responses. Always seek medical advice before starting this treatment to ensure it aligns with your individual health needs.
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2-0.5MG, Buprenorphine-naloxone (14 Tablet Sublinguals)

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CVS

$21.39

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$10.46

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$19.21

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$28.65

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Buprenorphine-naloxone dosage forms

The average cost for 14 Tablet Sublinguals of Buprenorphine-naloxone (generic Suboxone, Zubsolv, Bunavail) at 2-0.5MG is $9.98 with a free coupon. This is 11.21% off the average retail price of $89.04
DosageQuantityPrice fromPer unit
2-0.5MG14 Tablet Sublinguals$9.98$0.71
8-2MG14 Tablet Sublinguals$13.52$0.97

Buprenorphine-naloxone Warnings

This medication requires careful use due to several important safety concerns. Below is an overview of the associated risks and precautions. It's essential to follow your healthcare provider's instructions and consult them with any questions.

  • Risk of Addiction and Misuse: Suboxone contains buprenorphine, an opioid with potential for misuse and dependence. Misuse can lead to addiction and serious side effects, including slowed breathing and overdose. Always take Suboxone exactly as prescribed. This risk is higher for individuals with a history of substance use disorder or those taking more than the prescribed dose.

  • Respiratory Depression: Buprenorphine in Suboxone can cause dangerously slow breathing, which may be life-threatening. The risk increases when combined with substances like benzodiazepines, opioids, or alcohol. Those over 65, with COPD, or other conditions causing slow breathing, should be particularly cautious.

  • Opioid Overdose Risk: Patients treated for opioid use disorder are at risk of relapse and overdose, which can occur even at prescribed doses. Children are particularly vulnerable to fatal overdose if they accidentally ingest Suboxone. Risk factors include previous opioid overdose, high opioid doses, concurrent use of sedatives, and alcohol consumption.

  • Cognitive Impairment and Drowsiness: Suboxone may cause extreme drowsiness and difficulty concentrating. Alcohol and certain medications can exacerbate these effects. Older adults and those taking other sedatives should exercise caution.

  • Pregnancy Risks: Opioids, including Suboxone, can pass through the bloodstream to an unborn baby, leading to dependency. Use during pregnancy should be closely monitored by a healthcare provider.

  • Adrenal Insufficiency: Long-term use of Suboxone may reduce adrenal hormone levels, causing symptoms like nausea, fatigue, and dizziness. Immediate medical consultation is advised if these symptoms occur.

  • Withdrawal Symptoms: Sudden cessation or rapid dose reduction of Suboxone can cause withdrawal symptoms. Gradual tapering under medical supervision is recommended for long-term users.

  • Liver Damage: Buprenorphine may cause liver damage, ranging from mild to severe. Regular liver function tests are advised for those with a history of liver issues or hepatitis B or C.

  • Dental Issues: Use of buprenorphine dissolved in the mouth may lead to dental problems, such as cavities and tooth loss.

  • Heart Rhythm Concerns (QT Prolongation): Suboxone can prolong the QT interval, potentially leading to dangerous heart rhythms. Patients with heart conditions should be vigilant.

  • Low Blood Pressure: Suboxone can cause significant drops in blood pressure, particularly when standing. Stand up slowly to prevent dizziness or fainting.

  • Not for Opioid-Naïve Individuals: Suboxone is not suitable for pain management or individuals who have not previously taken opioids, as it may cause fatal overdoses.

Contraindications: Do not use Suboxone if you have a severe allergy to buprenorphine or naloxone. Always consult your healthcare provider before use if you have any contraindications.

Buprenorphine-naloxone Side Effects

Common side effects:

  • drowsiness
  • dizziness
  • headache
  • constipation
  • nausea
  • sweating
  • trouble sleeping
  • general pain

Less common but important to monitor:

  • mouth numbness
  • burning sensations in the mouth or tongue
  • swelling in the hands or ankles
  • body weakness
  • back pain
  • chills
  • runny nose
  • diarrhea
  • vomiting
  • signs of infection

Serious side effects:

  • severe breathing problems
  • heart rhythm issues
  • opioid withdrawal symptoms
  • serious liver disease
  • allergic reaction

Buprenorphine-naloxone Interactions

Interactions with high risk of serious adverse effects and should be avoided:

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

Buprenorphine-naloxone FAQs
What is buprenorphine naloxone used for?

Buprenorphine naloxone is used for the treatment of opioid dependence. It helps reduce withdrawal symptoms and cravings in individuals who are addicted to opioids, supporting them in their recovery process.

Buprenorphine can be used as a painkiller, particularly for moderate to severe pain. It is an opioid medication that works by binding to opioid receptors in the brain, providing pain relief. However, it is more commonly used in the treatment of opioid addiction. Its use for pain management should be carefully considered and monitored by a healthcare professional due to its potential for dependence and other side effects.

Buprenorphine is an active ingredient in Suboxone, but they are not the same. Suboxone is a combination medication that contains both buprenorphine and naloxone. Buprenorphine is used to help reduce withdrawal symptoms and cravings, while naloxone is included to deter misuse.

Naltrexone, methadone, and buprenorphine are all used in the treatment of opioid use disorder, but they function differently. Naltrexone is an opioid antagonist, meaning it blocks the effects of opioids and is used to prevent relapse in individuals who have already detoxified. Methadone is a full opioid agonist, which means it activates opioid receptors in the brain to reduce withdrawal symptoms and cravings. Buprenorphine is a partial opioid agonist, which activates opioid receptors but to a lesser extent than methadone, helping to reduce cravings and withdrawal symptoms with a lower risk of misuse.

Buprenorphine is considered a partial opioid agonist, which means it has a ceiling effect on its opioid activity. It is generally considered to be a strong opioid in terms of its binding affinity to opioid receptors, but it produces less euphoria and respiratory depression compared to full opioid agonists like morphine or heroin.