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Buprenorphine carries a risk of misuse and dependency, potentially resulting in overdose and death. It may also lead to serious or life-threatening respiratory issues. To minimize these risks, your healthcare provider should prescribe the lowest effective dose for the shortest duration necessary.

• Discuss with your doctor or pharmacist whether you should have naloxone on hand for emergency treatment of opioid overdose. Make sure that your family or household members are familiar with the signs of an opioid overdose and how to respond.
• The likelihood of severe breathing issues is elevated when beginning treatment, after a dose increase, or if the medication is used incorrectly (e.g., chewing or swallowing a patch). Combining this medication with alcohol or other substances that induce drowsiness or respiratory issues can result in serious adverse effects, including death.
• Ensure you understand how to take buprenorphine properly and which substances to avoid while using it.
• Seek immediate medical attention if you experience very serious side effects such as slow or shallow breathing, unusual lightheadedness, severe drowsiness or dizziness, or difficulty waking up.
• Store this medication securely to prevent theft, misuse, or abuse. If someone accidentally ingests or uses this medication, seek emergency medical assistance immediately due to the risk of fatal respiratory complications.

Women of childbearing age should consult their healthcare provider about the benefits and risks before using this medication. Inform your doctor if you are pregnant or planning to become pregnant. Use during pregnancy should only occur if clearly necessary, as it may slightly increase the risk of birth defects, particularly in the first two months. High doses or prolonged use near the delivery date might harm the unborn child. To reduce risk, use the minimal effective dose for the briefest time possible. Newborns exposed to this drug for extended periods may experience severe (possibly fatal) withdrawal symptoms. Contact a doctor immediately if your newborn shows signs such as incessant crying, slow or shallow breathing, irritability, shaking, vomiting, diarrhea, poor feeding, or difficulty gaining weight.

You may experience some common side effects such as nausea, vomiting, constipation, lightheadedness, dizziness, drowsiness, dry mouth, or headache. Irritation, itching, or redness can occur at the application site as well. These effects often improve over time. For constipation, consider increasing dietary fiber, staying hydrated, and exercising. A laxative might be necessary; consult your pharmacist for recommendations. To minimize dizziness and lightheadedness, rise slowly from sitting or lying down.

Serious side effects requiring immediate medical attention include sleep interruptions (sleep apnea), mental changes like agitation or hallucinations, difficulty urinating, swelling or blistering at the patch site, and signs of adrenal insufficiency such as unusual fatigue or weight loss. Urgent help is needed for very severe side effects like fainting, seizures, slow or shallow breathing, severe drowsiness, irregular heartbeat, or extreme dizziness.

Liver damage is a rare but serious risk. Symptoms include persistent nausea or vomiting, dark urine, appetite loss, yellowing of the skin or eyes, and severe abdominal pain. Although very rare, a serious allergic reaction can occur, indicated by rash, severe itching or swelling, dizziness, and breathing difficulties. Seek medical assistance immediately if these occur. If you experience any other unusual effects, contact your healthcare provider for advice.