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Buprenorphine is associated with risks of misuse and dependency, which may result in overdose and fatality. It can also induce serious, potentially life-threatening respiratory issues. To minimize these risks, it is critical that your healthcare provider prescribes the lowest effective dose for the shortest duration necessary.

• Overdose Preparedness: Consult your doctor or pharmacist about having naloxone on hand for opioid overdoses. Educate family or household members on recognizing and responding to signs of an overdose.
• Increased Risk Periods: Be aware that the likelihood of severe breathing problems is heightened when initiating treatment, after dosage increases, or if the incorrect dose/strength is used.
• Substance Interactions: Combining buprenorphine with alcohol or other substances that cause drowsiness or respiratory depression can lead to serious complications, including death. Ensure you understand which substances to avoid while taking buprenorphine.
• Emergency Symptoms: Seek immediate medical assistance if you experience symptoms such as slow or shallow breathing, intense lightheadedness, severe drowsiness or dizziness, or difficulty awakening.
• Proper Usage: Do not chew, swallow, or inject the buprenorphine film, as these actions can result in a fatal overdose.
• Storage and Safety: Store this medication securely to prevent theft, misuse, or abuse. In the event of accidental ingestion or use by others, seek medical help immediately.
• Use During Pregnancy: Women of childbearing age should discuss potential risks and benefits with their doctor before using this medication. If you are pregnant or planning to become pregnant, inform your healthcare provider. This medication should only be used during pregnancy if clearly necessary, as early pregnancy use may slightly increase birth defect risks. Prolonged or high-dose use near delivery may harm the unborn child. Infants born to mothers who have used this medication long-term may exhibit severe withdrawal symptoms. Contact your doctor immediately if you observe symptoms such as incessant crying, slow or shallow breathing, irritability, tremors, vomiting, diarrhea, poor feeding, or difficulty gaining weight in your newborn.

This medication may cause mild side effects such as nausea, vomiting, constipation, lightheadedness, dizziness, or drowsiness. These often improve over time. If they persist or worsen, consult your healthcare provider. To manage constipation, incorporate dietary fiber, stay hydrated, and exercise regularly; a pharmacist can recommend an appropriate laxative if needed. To minimize dizziness and lightheadedness, rise slowly from sitting or lying down.

Serious side effects are uncommon but require immediate medical attention. These include disrupted breathing during sleep (sleep apnea), mental or mood changes like agitation or confusion, stomach pain, tooth or gum discomfort, difficulty urinating, or symptoms indicating adrenal gland issues, such as fatigue or weight loss. Seek urgent help for very serious reactions such as fainting, irregular heartbeat, severe dizziness, seizures, or difficulty waking up.

Buprenorphine can rarely lead to severe liver damage. Contact a healthcare professional immediately if you experience persistent nausea or vomiting, loss of appetite, severe stomach pain, yellowing of the skin or eyes, or dark urine. Although rare, serious allergic reactions may occur. Seek urgent care if you notice rash, itching, swelling (particularly of the face, tongue, or throat), severe dizziness, or trouble breathing. This summary does not cover all possible side effects. If you notice other effects, contact your healthcare provider.

Certain medications can interact with this drug, including some pain relievers like butorphanol, nalbuphine, and pentazocine, as well as naltrexone and samidorphan. Using this drug with others that cause drowsiness or breathing issues can increase the likelihood of experiencing serious side effects, such as difficulty breathing or extreme drowsiness. Inform your doctor or pharmacist if you are using other opioid pain or cough medications (like codeine or hydrocodone), alcohol, cannabis, sleep or anxiety medications (such as alprazolam, lorazepam, or zolpidem), muscle relaxants (such as carisoprodol or cyclobenzaprine), or antihistamines (like cetirizine or diphenhydramine).

Review the labels on all your medicines, including those for allergies or cough-and-cold, as they might have ingredients that cause drowsiness. Consult your pharmacist for safe use of these products. Additionally, this drug might affect certain lab tests, such as those measuring amylase or lipase levels, leading to inaccurate results. Be sure to inform lab personnel and all your healthcare providers that you are taking this medication.