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The following information outlines vital safety warnings and precautions related to the use of tiagabine (Gabitril). It is crucial to thoroughly review these details and discuss any concerns with your healthcare provider.

• Intended Use: Tiagabine (Gabitril) is prescribed solely for individuals diagnosed with partial (focal) seizures when other treatments prove inadequate. It may induce seizures in those without a seizure disorder like epilepsy.

• Risk of Suicidal Thoughts: As with many antiepileptic medications, tiagabine (Gabitril) may increase the risk of suicidal thoughts or behavior. Be vigilant for any new or worsening depression or unusual mood changes, especially within the initial months of treatment or after a dosage adjustment. Any concerning symptoms should be immediately reported to a healthcare provider. In cases of suicidal thoughts, seek emergency medical assistance or call 911.

• Withdrawal Seizures: Abruptly discontinuing tiagabine (Gabitril) can lead to withdrawal seizures. It is essential to consult your healthcare provider before stopping the medication. If discontinuation is necessary, your provider will guide you on gradually reducing the dosage.

• Uncontrolled Seizure Episodes: In rare cases, tiagabine (Gabitril) use has been linked to status epilepticus, a condition requiring hospitalization that can result in long-term brain damage. If you have a history of status epilepticus, discuss this with your provider prior to starting the medication.

• Cognitive and Energy Impairments: Tiagabine (Gabitril) may impact brain function, causing difficulties with concentration, communication, and energy levels. These effects are generally mild, but if persistent or severe, inform your provider. Adjustments in dosage or an EEG (brain activity test) may be needed if these issues are related to seizures.

• Serious Rash: Although rare, serious rashes have occurred in individuals taking tiagabine (Gabitril). If a rash develops that affects large areas of the body or includes blisters, ulcers, or involves the eyes, mouth, or genitals, seek medical advice promptly.

Please note that there are no known contraindications for tiagabine (Gabitril). Always follow your healthcare provider's guidance when using this medication.

Common side effects:

• Dizziness
• Drowsiness
• Stomach pain
• Diarrhea
• Nausea
• Nervousness
• Tiredness
• Shaking

Less common but important to monitor:

• Vomiting
• Increased appetite
• Difficulty concentrating
• Movement or coordination challenges
• Difficulty walking
• Speech or language issues
• Memory problems
• Confusion
• Tingling sensations
• Mood swings
• Agitation
• Rash
• Itching

Serious side effects:

• Thoughts of self-harm or suicide
• More frequent or worsening seizures
• Severe allergic reactions (serious rash or difficulty breathing)

Interactions with high risk of serious adverse effects and should be avoided:

• Orlistat
• Calcifediol

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Carbamazepine
• Fosphenytoin
• Ginkgo
• Phenobarbital
• Phenytoin
• Primidone