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This medication contains abacavir and may lead to severe, potentially life-threatening allergic reactions. A preliminary blood test is advised to assess your risk before initiating or reinitiating treatment. If the test indicates a high risk, alternative treatments should be discussed with your healthcare provider. Be vigilant for symptoms of an allergic reaction, such as rash, swelling (particularly of the face, tongue, or throat), severe dizziness, difficulty breathing, fever, fatigue, nausea, vomiting, diarrhea, stomach pain, muscle or joint pain, sore throat, mouth sores, blisters, eye redness or swelling, or cough. Seek immediate medical attention if these occur. If you have previously experienced an allergic reaction to abacavir, you must never take it again, as it could be fatal. Inform all of your healthcare providers if you've discontinued abacavir due to an allergic reaction and dispose of any remaining medication properly.

Before starting this medication, testing for hepatitis B is necessary. If co-infected with hepatitis B and HIV, additional treatment for hepatitis B may be required. Discontinuing lamivudine can exacerbate hepatitis symptoms; always consult your doctor before stopping. Your liver function should be monitored for several months post-treatment cessation. If liver problems worsen, seek immediate medical care.

• Potential Risks:

  • Severe allergic reactions, particularly if genetic tests indicate susceptibility.
  • Worsening of hepatitis B symptoms if treatment is stopped abruptly.
  • Possible serious liver complications, particularly in individuals with obesity, females, or those with hepatitis B or C, or who have had a liver transplant.
  • Overactivity of the immune system, potentially leading to autoimmune disorders.

• Precautions:

  • Conduct genetic testing for abacavir allergy risk.
  • Monitor liver function continuously, especially in those with pre-existing liver conditions.
  • Regularly assess for immune system changes or new symptoms.

• Special Instructions for Specific Populations:

  • Individuals with a history of severe allergy to abacavir, dolutegravir, or lamivudine should avoid this medication.
  • Those with existing liver problems should consult their healthcare provider to determine safe usage.

• Interactions with Other Substances:

  • Certain medications may interfere with the efficacy and safety of this treatment.
  • Avoid concurrent use with dofetilide (Tikosyn).

• Emergency Actions in Case of Overdose:

  • In the event of an overdose, seek immediate medical assistance. Regular monitoring and communication with your healthcare provider are crucial to ensure safe and effective use of this medication.

When taking this medication, it's important to be aware of potential side effects, ranging from mild to severe. Common side effects include increased lipase levels, which may indicate pancreatic irritation, elevated blood sugar levels, and higher creatine kinase levels suggesting possible muscle damage. Some individuals also experience elevated fat levels in the blood, an increased white blood cell count, abnormal liver tests, trouble sleeping, headaches, and feelings of tiredness. These effects are generally mild, but if they persist or worsen, consulting a healthcare provider is advisable.

Other side effects reported include depression, strange dreams, dizziness, nausea, diarrhea, and rashes. Although these are less common, they should still be monitored, especially if they become severe.

Serious side effects, though rare, demand immediate medical attention. These include severe allergic reactions characterized by fever, rash, extreme tiredness, and respiratory issues, as well as significant liver problems such as persistent nausea, vomiting, loss of appetite, jaundice, and dark urine. Additionally, excessive lactic acid in the blood can cause weakness, dizziness, stomach pain, and rapid heartbeat, which also require urgent care.

In rare cases, the medication may lead to severe liver damage or lactic acidosis, with symptoms such as persistent nausea, vomiting, abdominal pain, jaundice, and deep breathing. These conditions are more prevalent in women and individuals with obesity. Recognizing these symptoms early and seeking medical intervention can prevent serious health outcomes. Always monitor for any side effects and discuss them with a healthcare professional.