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When taking Genvoya, it is crucial to be aware of the potential risks and necessary precautions. Below are the key safety warnings and instructions to follow. Consult your healthcare provider if you have any questions or concerns.

• Hepatitis B Warning: If you are infected with hepatitis B virus (HBV), stopping Genvoya suddenly can exacerbate your liver condition, potentially leading to severe liver issues. It is important not to stop this medication without consulting your healthcare provider. Regular liver function tests will be conducted for several months after discontinuing the medication to monitor your liver health. Ensure you have consistent access to your medication to avoid interruptions in treatment.

• Kidney Health: Genvoya has been associated with kidney issues in some individuals. Before and during treatment, your healthcare provider will perform blood or urine tests to monitor your kidney function. Those with existing kidney conditions or who take medications that may affect the kidneys should exercise caution. Report any persistent muscle or bone pain, limb discomfort, or general fatigue to your healthcare provider, as these may be signs of kidney problems.

• Liver Conditions and Lactic Acidosis: There is a rare risk of liver problems, including fatty liver disease, and lactic acidosis, a serious condition resulting from lactic acid buildup. Both can be life-threatening, so immediate medical attention is required if symptoms occur.

• Immune System Changes: The use of Genvoya can lead to immune reconstitution syndrome, a condition where the immune system becomes more active and may attack infections or, in rare cases, normal cells. Symptoms such as fever, hair loss, or eye changes should be reported to your healthcare provider immediately.

• Drug Interactions: Certain medications and supplements, including those for seizures (e.g., carbamazepine), bacterial infections (e.g., rifampin), oral steroids (e.g., dexamethasone), and herbal supplements like St. John's wort, can reduce the effectiveness of Genvoya. Discuss all medications and supplements you are taking with your healthcare provider.

• Contraindications: Genvoya should not be used with certain medications due to potential serious interactions. These include alfuzosin, lovastatin, and carbamazepine. Consult your healthcare provider if you are taking these or similar medications before starting Genvoya.

• Emergency Measures: In case of an overdose, seek immediate medical attention.

By adhering to these guidelines and maintaining open communication with your healthcare provider, you can help ensure the safe and effective use of Genvoya.

When taking this medication, some individuals may experience common side effects such as nausea, diarrhea, headaches, or feelings of tiredness. These effects are usually mild, but if they persist or worsen, it is advisable to consult with your healthcare provider.

In some cases, users may experience skin-related issues such as a rash or itching, and swelling known as angioedema. If these occur, especially in a severe form, contacting a healthcare provider is recommended.

There are rare but serious side effects that require immediate medical attention. These include symptoms of lactic acidosis, such as extreme tiredness, weakness, abdominal pain, muscle pain, and breathing difficulties. Kidney problems may manifest as fatigue, confusion, nausea, reduced urination, swelling in the legs, or joint and bone pain. Liver issues could present as persistent nausea, vomiting, loss of appetite, right-side stomach pain, yellowing of the eyes or skin, dark urine, or light-colored stools.

Additionally, as the immune system strengthens, it might reactivate previous infections, leading to symptoms like unexplained weight loss, severe tiredness, muscle aches, persistent headaches, joint pain, numbness, vision changes, or signs of infection. An overactive immune response could also cause irritability, nervousness, heat intolerance, rapid heartbeat, or a thyroid growth. Rarely, Guillain-Barre syndrome might occur, leading to coordination loss, swallowing or speaking difficulties, and eye movement issues. Severe allergic reactions, characterized by rash, severe dizziness, or breathing difficulties, are also very rare but require urgent medical assistance.

This medication can interact with several other drugs. Avoid taking it with adefovir, orlistat, and other medications that may impact kidney function, including aminoglycosides like amikacin or gentamicin. It should not be used alongside certain HIV medications, such as ritonavir, or products containing cobicistat, elvitegravir, emtricitabine, lamivudine, or tenofovir.

This drug can slow the elimination of other medications from your body, potentially altering their effectiveness. Affected drugs include dronedarone, eletriptan, eplerenone, ergot alkaloids (e.g., ergotamine, dihydroergotamine), salmeterol, tolvaptan, rivaroxaban, some alpha blockers (such as alfuzosin, tamsulosin), certain benzodiazepines (like midazolam, triazolam), specific statins (such as lovastatin, simvastatin), and medications for erectile dysfunction or pulmonary hypertension like avanafil and sildenafil.

Conversely, some medications can alter the removal of this drug from your body, affecting its efficacy. Examples include mitotane, rifampin, St. John's wort, and certain seizure medications (e.g., carbamazepine, oxcarbazepine, phenobarbital, phenytoin, primidone).

Additionally, this medication may reduce the effectiveness of hormonal birth control methods, such as pills, patches, or rings, potentially leading to pregnancy. It may also increase certain side effects of hormonal contraceptives. Consult your doctor about alternative birth control options and use effective barrier methods, like latex or polyurethane condoms or dental dams, during sexual activity to prevent HIV transmission. Notify your doctor if you experience any new spotting or breakthrough bleeding, as these might indicate that your hormonal birth control is less effective.