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Abacavir

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generic Ziagen

Abacavir, known by the brand name Ziagen, is a medication used in combination with other antiretroviral drugs to manage HIV infection. It is crucial to have a genetic test before starting Abacavir, as it may cause a severe allergic reaction in some individuals. As a nucleoside reverse transcriptase inhibitor (NRTI), Abacavir works by mimicking a DNA building block. This action interrupts the DNA synthesis process, preventing the HIV virus from replicating. Although not a cure for HIV, Abacavir helps reduce the viral load in your body, bolsters your immune system, decreases the risk of HIV-related complications like infections and cancer, and enhances your overall quality of life. To prevent the transmission of HIV, continue taking all prescribed medications correctly and use effective barrier methods, such as condoms or dental dams, during sexual activity. Additionally, avoid sharing personal items that may have been in contact with blood or other body fluids. For further guidance, consult with your healthcare provider.
Our coupons are free to use. Before paying, show the pharmacist your Abacavir savings card to get your free discount. Use our filters below to edit the prescription box to match your needs. The Abacavir prices will update based on your prescription needs. Above our Abacavir coupons, you can change your location to see pharmacy prices and costs in other areas. We're here to help you buy Abacavir at the lowest price with our prescription discount card.

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300MG, Abacavir (30 Tablets)

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CVS

$32.58

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$22.59

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$76.31

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Abacavir dosage forms

The average cost for 30 Tablets of Abacavir (generic Ziagen) at 300MG is $21.08 with a free coupon. This is 7.00% off the average retail price of $301.2
DosageQuantityPrice fromPer unit
300MG30 Tablets$21.08$0.7

Abacavir Warnings

When using abacavir, it is crucial to be aware of the potential risks and necessary precautions to ensure safe use. Below are important safety warnings and guidelines for patients and healthcare professionals:

  • Serious Allergic Reactions: Abacavir can cause severe allergic reactions that may be life-threatening or even fatal. Such reactions typically occur within the first six weeks of treatment. A genetic test (HLA B5701) is mandatory before starting this medication to assess your risk. If the test is positive or there is a history of allergic reactions to abacavir, you must avoid this medication and any combination tablets containing it, like Epzicom or Triumeq. Symptoms of an allergic reaction include rash, itching or swelling (especially of the face, tongue, or throat), severe dizziness, trouble breathing, fever, extreme tiredness, nausea, vomiting, diarrhea, stomach pain, muscle aches, sore throat, or cough. Discontinue use immediately and seek emergency medical assistance if symptoms arise.

  • Liver Issues: Though rare, abacavir can cause a serious liver condition known as lactic acidosis with hepatic steatosis, predominantly affecting women. Watch for symptoms such as loss of appetite, stomach pain, muscle pain, rapid and shallow breathing, extreme fatigue, and sudden weakness. Immediate emergency care is required should these symptoms occur. Women, individuals with obesity, or those with a history of liver problems are at an increased risk.

  • Immune Reconstitution Syndrome: As your immune system recovers with HIV treatment, it may start to aggressively combat existing infections, leading to significant inflammation. Healthcare providers should screen for underlying infections before commencing treatment with abacavir, particularly for first-time users of HIV medications. Contact your healthcare provider if you experience fever, difficulty breathing, or any sudden health changes post-treatment. Those with a weakened immune system or current untreated infections are at higher risk.

  • Increased Risk of Heart Attack: Patients on abacavir may have a heightened risk of heart attack, especially if they have high blood pressure, high cholesterol, or diabetes. It is vital to discuss your full medical history and current medications with your HIV provider to assess this risk properly.

In cases of overdose, seek immediate medical attention. Always inform your healthcare team if you have discontinued abacavir due to an allergic reaction, and dispose of any remaining medication appropriately. For further details, consult the warning card provided with your prescription.

Abacavir Side Effects

Common side effects:

  • Headaches
  • Nausea
  • Fatigue
  • Diarrhea
  • Rash
  • Stomach pain
  • Dizziness
  • Muscle pain

Less common but important to monitor:

  • Cough
  • Vomiting

Serious side effects:

  • Unexplained weight loss
  • Severe fatigue
  • Persistent muscle aches or weakness
  • Severe or unrelenting headaches
  • Joint pain
  • Numbness or tingling in the limbs
  • Changes in vision
  • Signs of infection (fever, chills, swollen lymph nodes, difficulty breathing, persistent cough)
  • Symptoms of liver problems (persistent nausea or vomiting, abdominal pain, yellowing of the eyes or skin, dark urine)
  • Signs of lactic acidosis (deep or rapid breathing, drowsiness)
  • Severe liver issues
  • Lactic acidosis

Abacavir Interactions

Interactions with high risk of serious adverse effects and should be avoided:

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

  • Methadone
  • Tipranavir

Interactions with low risk that usually do not require a change in therapy:

  • Alcohol
Abacavir FAQs
What is the main side effect of abacavir?

The main side effect of abacavir is a hypersensitivity reaction, which can be severe and potentially life-threatening. This reaction typically involves symptoms such as fever, rash, gastrointestinal issues, and respiratory problems. It is important for patients to be screened for the HLA-B*5701 allele before starting abacavir, as those with this genetic marker are at higher risk for the hypersensitivity reaction.

Abacavir and lamivudine are both classified as nucleoside reverse transcriptase inhibitors (NRTIs). They are used in combination as part of antiretroviral therapy for the treatment of HIV infection.

Abacavir has not been discontinued. It is still available and used as part of antiretroviral therapy for the treatment of HIV infection. However, it is important for patients to be screened for the HLA-B*5701 allele before starting abacavir, as this genetic marker is associated with a higher risk of hypersensitivity reactions to the drug.

Abacavir should not be taken by individuals who have a known hypersensitivity to the drug or any of its components. Additionally, those who test positive for the HLA-B*5701 allele are at a higher risk for hypersensitivity reactions and should avoid taking abacavir. It is also contraindicated in individuals with moderate to severe hepatic impairment. As always, it is important for patients to consult with their healthcare provider before starting any new medication.

Abacavir is a nucleoside reverse transcriptase inhibitor (NRTI). Its mechanism of action involves inhibiting the activity of reverse transcriptase, an enzyme crucial for the replication of HIV. By incorporating itself into the viral DNA, abacavir causes premature chain termination, thereby preventing the virus from multiplying and spreading in the body.