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The medication described here offers significant benefits for individuals with irregular heartbeats; however, it also presents potential risks that require careful consideration. Please review the following safety information and discuss any concerns with your healthcare provider.

• Risk of New Irregular Heartbeat: Although beneficial, this medication can rarely cause a serious new irregular heartbeat. Initial treatment may require hospital monitoring to ensure safety.

• Increased Risk of Death or Cardiac Arrest: Individuals who have experienced a heart attack within the past two years may face an increased risk of sudden death or cardiac arrest when using this medication. It is crucial to discuss your medical history with your healthcare provider to determine the most appropriate treatment based on your symptoms and EKG results.

• Liver Health Concerns: There have been rare reports of serious liver complications in individuals taking this medication, particularly within the first few weeks of treatment and among those with existing heart conditions. Regular blood tests may be necessary to monitor liver function. If you experience symptoms like fatigue, upper right abdominal pain, yellowing of the skin or eyes, or dark urine, contact your healthcare professional immediately.

• Severe Allergic Reactions: In rare instances, this medication may provoke severe allergic reactions, potentially leading to organ failure or blood disorders. Seek medical attention promptly if you notice symptoms such as sudden rashes, mouth sores, fever, chills, body aches, or swollen lymph nodes.

• Potential for Worsening Heart Rhythm: This medication can exacerbate abnormal heart rhythms, potentially leading to life-threatening arrhythmias. To mitigate risk, initial doses are often administered in a hospital setting to monitor heart electrical activity. Report any unusual heart rate, chest discomfort, weakness, dizziness, or fainting to your healthcare provider immediately.

• Impact on Low Blood Pressure and Heart Failure: For individuals with existing low blood pressure or heart failure, this medication may worsen these conditions. Inform your healthcare provider of your medical history, and report any symptoms like dizziness, fainting, shortness of breath, or swelling in the extremities.

• Lower Blood Cell Counts: Although very rare, some may experience a decrease in white blood cell or platelet counts, increasing the risk of infections and bleeding. Blood cell counts generally return to normal within a month after discontinuing the medication. Report symptoms of infection or unusual bleeding to your provider.

• Drug Interactions: Certain medications can affect how your body processes this drug, influencing its efficacy and increasing the risk of side effects. Discuss any other medications you are taking with your healthcare provider.

• Contraindications: This medication should not be used in cases of cardiogenic shock or a history of second- or third-degree heart block. Consult your healthcare provider if these conditions apply to you.

In case of an overdose, seek emergency medical assistance immediately. Always follow your healthcare provider's instructions and report any adverse effects or concerns.

Common side effects:

• Nausea
• Vomiting
• Heartburn
• Dizziness
• Lightheadedness

Less common but important to monitor:

• Blurred vision
• Headache
• Shaking
• Nervousness
• Trouble sleeping
• Problems with muscle coordination

Serious side effects:

• Worsening symptoms of heart failure
• Shortness of breath
• Swelling of the feet or ankles
• Unusual tiredness
• Sudden weight gain
• Signs of liver problems
• Persistent nausea or vomiting
• Abdominal pain
• Yellowing of the skin or eyes
• Dark urine
• Serious cardiovascular issues
• Chest pain
• Low blood pressure
• Abnormal heart rhythm
• Severe allergic reactions
• Fever
• Swollen lymph nodes
• Rash
• Severe dizziness
• Trouble breathing

Interactions with high risk of serious adverse effects and should be avoided:

• Levomethadyl
• Vernakalant

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Abametapir
• Amiodarone
• Anagrelide
• Bupropion
• Capmatinib
• Clozapine
• Cobicistat
• Dasabuvir
• Disopyramide
• Etravirine
• Lacosamide
• Lidocaine
• Ombitasvir
• Paritaprevir
• Paroxetine
• Pexidartinib
• Pirfenidone
• Pixantrone
• Prilocaine
• Quinidine
• Simeprevir
• Sotalol
• Theophylline
• Tizanidine

Interactions with low risk that usually do not require a change in therapy:

• Caffeine
• Fezolinetant
• Sodium Bicarbonate
• Vitamin C
• Cimetidine
• Fluvoxamine
• Propafenone
• Phenytoin
• Phenobarbital
• Rifapentine
• Ritonavir