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The following safety information outlines crucial risks and precautions associated with using this medication. Please read carefully and discuss any concerns with your healthcare provider.

• Liver and Kidney Concerns: Apraclonidine, though applied to the eyes, may enter the bloodstream, potentially accumulating in individuals with liver or kidney issues. If you have such conditions, inform your doctor, as monitoring of blood pressure and heart rate may be necessary.

• Low Blood Flow Complications: The medication might lower blood pressure, which could exacerbate conditions involving inadequate blood flow to the brain, heart, extremities, or other areas. If you suffer from high blood pressure, severe heart conditions, recent heart attacks, previous strokes, kidney failure, Raynaud's disease, or Buerger's disease, notify your healthcare provider.

• Dizziness and Drowsiness: This medication may cause dizziness or drowsiness. Avoid driving or engaging in activities that require full alertness until you understand how apraclonidine affects you.

• Allergic Reactions: Some individuals may experience allergic reactions, including redness, itching, discomfort, tearing, or swelling of the eyes or eyelids. Contact your healthcare provider if these symptoms occur.

Contraindications

This medication should not be used if you have any of the following conditions, as it could lead to serious health issues. Consult your healthcare professional if you are:

• Taking monoamine oxidase inhibitors (MAOIs).
• Allergic to apraclonidine or clonidine.

Always follow your healthcare provider's advice and report any adverse effects you experience while using this medication.

Common side effects:

• eye discomfort
• redness
• itching
• dry mouth
• blurred vision
• eye inflammation
• dry eye
• sensation of something in the eye
• changes to eyelid
• tearing

Less common but important to monitor:

• irregular or abnormal heartbeat
• mood changes
• mental changes
• irritability
• depression

Serious side effects:

• severe allergic reaction
• rash
• significant itching or swelling
• severe dizziness
• trouble breathing

Interactions with high risk of serious adverse effects and should be avoided:

• MAO inhibitors (isocarboxazid, Linezolid, Metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, Rasagiline, safinamide, Selegiline, Tranylcypromine)

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Iobenguane I 131

Interactions with low risk that usually do not require a change in therapy:

• Alcohol
• Marijuana (cannabis)
• Antihistamines (Cetirizine, diphenhydramine)
• Sleep or anxiety medications (Alprazolam, Diazepam, Zolpidem)
• Muscle relaxants
• Opioid pain relievers (codeine)