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When utilizing Ranolazine (Ranexa), it is crucial to be aware of key safety information to ensure proper use and mitigate risks. Below are important points to consider:

• Abnormal Heart Rhythm: Ranolazine (Ranexa) can disrupt the heart's natural rhythm, potentially leading to irregular heartbeats. Regular monitoring through electrocardiograms (EKGs) by your healthcare provider is advised. Do not exceed the prescribed dosage. Inform your healthcare provider if you or your family have a history of "long QT" syndrome. Alert your provider and pharmacist about all medications you are taking, as some can exacerbate this condition. Seek immediate medical attention if you experience abnormal heart rate, chest pain, dizziness, breathing difficulties, or fainting.

  • Risk Factors: Personal or familial history of "long QT" syndrome, concurrent use of medications that prolong the QT interval.

• Kidney Problems: This medication may impair kidney function, particularly in those with pre-existing kidney issues. Your provider may conduct regular blood tests to monitor kidney health. If you notice changes in urination frequency, blood or foam in urine, fatigue, dry or itchy skin, muscle cramps, or reduced appetite, contact your provider immediately as these may indicate kidney problems.

  • Risk Factors: History of severe kidney conditions.

• Drug Interactions: Ranolazine (Ranexa) can interact with various medications, potentially affecting how drugs are metabolized and increasing the likelihood of side effects. It is important to discuss all current medications with your healthcare provider.

  • Risk Factors: Use of multiple medications.

Contraindications:

• Ranolazine (Ranexa) should not be used if you are taking certain medications that interact negatively with it.
• Individuals with liver cirrhosis should avoid this medication.

Always consult your healthcare provider for personalized advice and before making any changes to your medication regimen.

When taking this medication, you may experience some common side effects such as dizziness, headache, constipation, nausea, and tiredness. These are generally mild and often resolve on their own. To minimize dizziness and lightheadedness, try getting up slowly from sitting or lying down. If these symptoms persist or worsen, it's important to consult your healthcare provider for further advice.

In some cases, you may notice other side effects like dry mouth, stomach pain, vomiting, or swelling in the arms or legs. Palpitations, or a racing heart, can also occur. While these effects are typically not severe, you should contact your healthcare provider if they become bothersome or persistent.

There are rare but serious side effects associated with this medication that require immediate medical attention. These include abnormal heart rhythms, characterized by dizziness, difficulty breathing, or chest pain, and serious kidney issues, such as changes in urination or swelling in the feet and ankles. Additionally, be aware of signs of a severe allergic reaction, such as rash, itching, swelling of the face, tongue, or throat, and trouble breathing. Seek emergency help if you experience any of these symptoms. Always stay informed and in communication with your healthcare provider regarding any unusual or concerning reactions.

Ranolazine (Ranexa) can interact with a variety of medications and supplements. It is important to inform your doctor and pharmacist about all the medications and supplements you are taking, including prescription, over-the-counter, vitamins, and herbal products. Certain medications can influence how ranolazine is processed in your body, impacting its effectiveness.

Some medications should not be used with ranolazine, as they can lead to significant interactions. These include azole antifungals like Itraconazole and Ketoconazole, Clarithromycin, cobicistat, Nefazodone, various HIV protease inhibitors such as nelfinavir, and rifamycins like Rifabutin and Rifampin. Medications used for seizures, such as Carbamazepine, Phenobarbital, and Phenytoin, as well as St. John's wort, are also on this list.

Additionally, there are medications that are usually not recommended to be combined with ranolazine unless necessary. If these medications are prescribed together, your doctor may need to adjust the dosage or frequency. This list includes Amiodarone, Alprazolam, Citalopram, diltiazem, Erythromycin, Fluconazole, and others.

Finally, combining ranolazine with certain medications like Metformin may increase the risk of side effects; however, in some cases, using both may be necessary. Your healthcare provider will determine the best course of action and may adjust dosages accordingly. Always follow your healthcare provider's guidance when taking ranolazine with other medications.