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The following safety information outlines important warnings and precautions for the use of glipizide. Please review these details carefully and speak with your healthcare provider if you have any questions or concerns.

• Low Blood Sugar Levels: Glipizide can lead to dangerously low blood sugar levels, particularly if combined with other blood sugar-lowering medications like insulin, or if meals are skipped after taking a dose. Initial treatment may require more frequent blood sugar monitoring. Symptoms of low blood sugar include shakiness, anxiety, rapid heartbeat, sweating, chills, confusion, and intense hunger. Be cautious if you miss meals, drink alcohol, engage in intense exercise, or have kidney, liver issues, or are older.

• Risk of Low Red Blood Cell Count (Hemolytic Anemia): Individuals with low levels of glucose-6-phosphate dehydrogenase (G6PD) are at increased risk of hemolytic anemia with glipizide. If you have a genetic predisposition for this condition, your healthcare provider may recommend an alternative medication. Report symptoms like weakness, fatigue, or dizziness to your provider.

• Possible Risk of Serious Heart Problems: There is a potential risk of increased heart-related mortality associated with sulfonylureas, a class of medications that includes glipizide. If you experience symptoms such as chest pain, sweating, nausea, dizziness, difficulty breathing, fatigue, swelling, or sudden weight gain, seek medical attention immediately. Your healthcare provider may advise discontinuing glipizide.

• Risk of Harm in People with Certain Stomach Problems (Extended-Release Tablets): The non-dissolvable coating of extended-release glipizide tablets can cause complications in individuals with specific gastrointestinal conditions, such as strictures. If you have such conditions, you should not take extended-release glipizide.

Contraindications: Glipizide should not be used in the following conditions, as it may pose serious health risks:

• Allergy to sulfonamide medications
• Type 1 diabetes
• Diabetic ketoacidosis

Consult your healthcare provider if any of these contraindications apply to you before starting glipizide.

When taking this medication, some individuals may experience common side effects such as nausea, vomiting, diarrhea, constipation, upset stomach, or passing gas. Headaches and weight gain are also possible. These effects are typically mild, but if they persist or worsen, it's advisable to consult your healthcare provider. An empty tablet shell might occasionally appear in your stool, which is harmless.

More serious side effects, though rare, require immediate attention. These include signs of infection like a persistent sore throat or fever, easy bleeding or bruising, liver issues indicated by abdominal pain or yellowing skin, unusual tiredness, sudden weight gain, mood changes, and swelling of the hands or feet. Seizures are also a critical concern.

This medication can cause both low and high blood sugar. Symptoms of low blood sugar include sweating, shaking, fast heartbeat, hunger, dizziness, and tingling in the hands or feet. Carry glucose tablets or a quick sugar source to manage this. High blood sugar symptoms like increased thirst and urination also require prompt medical advice.

Lastly, serious allergic reactions are rare but require urgent medical help if symptoms such as rash, severe dizziness, or trouble breathing occur. Always communicate any unexpected effects to your healthcare provider to ensure proper management and care.

Some medications can impact blood sugar levels, making diabetes management more challenging. Before starting, stopping, or changing any medication, consult your doctor or pharmacist to understand how it might influence your blood sugar. Regularly monitor your blood sugar as instructed and share these results with your healthcare provider. If you experience symptoms of high or low blood sugar, inform your doctor promptly. Adjustments to your diabetes medication, exercise routine, or diet may be necessary.

Beta-blockers, such as metoprolol, Propranolol, and certain glaucoma eye drops like timolol, can mask the rapid heartbeat typically felt during low blood sugar (hypoglycemia). However, other low blood sugar symptoms, including dizziness, hunger, or sweating, remain unchanged by these drugs.

Additionally, Glipizide may interact with various medications or supplements. Always inform your healthcare team about all medications and supplements you are taking, including prescription, over-the-counter, vitamins, and herbal products. Some medications, like Acarbose, Aspirin, and Ciprofloxacin, among others, might require dose adjustments if used alongside Glipizide. Other drugs, such as Acebutolol, Cimetidine, and Propranolol, may raise the risk of side effects but could still be necessary for your treatment. Your doctor may modify how you take one or both medicines to manage these interactions effectively.