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This document outlines important safety and warning information for those considering or currently using acetazolamide. It is crucial to read these details carefully and discuss any questions with your healthcare provider.

• Electrolyte and Acid-Base Imbalances: Acetazolamide may lead to imbalances in electrolytes such as sodium and potassium, and can cause metabolic acidosis, especially if you have kidney or respiratory issues. Notify your healthcare provider if you experience symptoms like nausea, muscle cramps, fatigue, rapid breathing, or confusion. Individuals with kidney issues, respiratory problems, diabetes, or who are aged 65 and older may face increased risks.

• Blood Sugar Changes: This medication can affect blood sugar levels. Diabetic patients should continue monitoring their blood sugar while on acetazolamide and report any unusual increases to their healthcare provider. Be aware of low blood sugar symptoms, such as shakiness, anxiety, or a rapid heartbeat, and consult your provider if these occur.

• Aspirin Interaction: Avoid using high-dose aspirin with acetazolamide as it may lead to adverse effects such as loss of appetite, breathing difficulties, fatigue, or in severe cases, coma or death. Consult your healthcare provider before combining these medications.

• Allergic Reactions: Allergic reactions to acetazolamide, which is a sulfonamide medication, can be severe and include skin rashes, fever, blood disorders, and anaphylaxis. Individuals with sulfa allergies or sensitivity to FD&C Yellow No. 6 dye should be cautious. If you notice symptoms like hives, blistered skin, breathing difficulties, or swelling of the tongue or throat, discontinue use immediately and seek emergency medical attention.

• Pregnancy Risks: The effects of acetazolamide on an unborn child are not fully understood, although animal studies have shown potential for birth defects. Weigh the benefits against the potential risks with your healthcare provider if you are pregnant or planning to become pregnant.

Contraindications: Acetazolamide is contraindicated in the following conditions, and consultation with a healthcare provider is necessary if any apply to you:

• Hyponatremia (low sodium levels)
• Hypokalemia (low potassium levels)
• Severe kidney or liver problems, including liver cirrhosis
• Adrenal gland failure
• Hyperchloremic acidosis
• Long-term use in individuals with chronic angle-closure glaucoma

Please ensure that you discuss any potential concerns with your healthcare provider before starting or continuing treatment with acetazolamide.

Common side effects:

• dizziness
• lightheadedness
• increased urination
• tiredness
• headache
• nausea
• vomiting
• diarrhea
• blurred vision
• dry mouth
• drowsiness
• loss of appetite
• changes in taste

Less common but important to monitor:

• numbness or tingling in the face, arms, or legs
• ringing in the ears (tinnitus)

Serious side effects:

• rash
• itching or swelling (especially of the face, tongue, or throat)
• severe dizziness
• trouble breathing
• unusual tiredness
• easy bleeding/bruising
• fast or irregular heartbeat
• muscle cramps
• new or worsening eye pain
• decreased vision
• mental or mood changes
• signs of liver or kidney problems

Interactions with high risk of serious adverse effects and should be avoided:

• Methenamine
• High doses of Aspirin

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Memantine
• Topiramate
• Zonisamide
• Ibuprofen
• Naproxen
• Acyclovir
• Adefovir
• Amphetamine
• Arsenic Trioxide
• Benzphetamine
• Carbamazepine
• Ceritinib
• Dextroamphetamine
• Digitalis
• Droperidol
• Furosemide
• Levomethadyl
• Lisdexamfetamine
• Methamphetamine
• Methotrexate
• Porfimer
• Proscillaridin
• Quinidine
• Sotalol
• Valacyclovir