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Taking this medication may lead to some mild side effects, such as feeling drowsy or dizzy, experiencing tiredness, having a dry mouth, nausea, headaches, or difficulty sleeping. These are generally not serious and often subside as your body adjusts to the medication. However, if they persist or worsen, it is wise to consult with a healthcare professional.

There are rare but more serious side effects to be aware of, such as difficulty urinating, a fast or irregular heartbeat, trembling, and changes in mood or mental state, including feelings of anxiety, confusion, or restlessness. If you experience any of these, it is important to notify a healthcare provider promptly.

In very rare instances, this medication can cause seizures or a severe allergic reaction. Signs of an allergic reaction include a rash, itching or swelling, particularly of the face, tongue, or throat, severe dizziness, or trouble breathing. These symptoms require immediate medical attention.

Please remember this is not a comprehensive list of side effects. If you notice other unexpected symptoms, reaching out to a healthcare professional is recommended for further guidance.

Avoid using MAO inhibitors like isocarboxazid, linezolid, or selegiline while on this medication, as combining them can lead to a severe, potentially fatal reaction. Most MAO inhibitors should not be taken for at least two weeks before starting this medication. Consult your doctor about when to begin or discontinue use. Inform your healthcare provider if you are using other substances that cause drowsiness, including opioid painkillers (e.g., codeine, hydrocodone), alcohol, cannabis, sleep aids or anxiety medications (e.g., alprazolam, lorazepam), muscle relaxants (e.g., carisoprodol, cyclobenzaprine), or other antihistamines (e.g., chlorpheniramine, diphenhydramine).

Be sure to read the labels on all your medications, particularly those for allergies or cough-and-cold, as they might contain ingredients that cause drowsiness or have similar compounds like decongestants (e.g., phenylephrine). Consult your pharmacist for safe usage advice. Do not apply other topical antihistamines, such as diphenhydramine creams or sprays, as they can increase side effects.

Cetirizine is closely related to hydroxyzine and levocetirizine, so do not use these medications concurrently. This medication can affect certain lab tests, like allergy skin tests, potentially leading to inaccurate results. Ensure all lab personnel and doctors are aware that you are taking this medication.