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When using chlorothiazide, it is essential to be aware of certain safety information and warnings. These highlight potential risks and precautions to consider. Please review these points carefully and consult your healthcare provider with any questions or concerns:

• Dehydration and Electrolyte Imbalance: Excessive use of chlorothiazide can lead to increased urination, which might cause dehydration and disturb electrolyte balance, notably sodium, potassium, magnesium, or chloride. Be alert for symptoms such as dry mouth, weakness, fatigue, dizziness, muscle pain or cramps, increased heart rate, vomiting, or nausea. These effects are more likely if you have impaired kidney function, an existing electrolyte imbalance, or are exposed to hot weather.

• Low Blood Pressure: This medication lowers blood pressure, which might result in lightheadedness or dizziness. The effects can be pronounced if combined with alcohol or other blood pressure-lowering drugs. It is advisable to limit alcohol consumption while using chlorothiazide.

• Worsening Kidney Issues: Chlorothiazide has the potential to impair kidney function. Regular blood tests are recommended to monitor kidney health before starting the medication and at least annually thereafter, especially if you have a history of kidney problems.

• Elevated Blood Sugar Levels: There is a risk of increased blood sugar levels with chlorothiazide use. Individuals with diabetes should monitor their blood sugar more frequently, and this should be discussed with your healthcare provider.

• Gout: This medication may elevate uric acid levels, potentially triggering or aggravating gout. This risk is higher if you have a history of gout or current kidney issues.

• Parathyroid Disease: Chlorothiazide can affect calcium excretion, which may impact the parathyroid gland. Discuss any concerns with your healthcare provider.

In case of an overdose or severe side effects, seek immediate medical attention. Always follow your healthcare provider's instructions regarding medication use and interactions with other substances.

Common side effects:

• Dizziness
• Low blood pressure
• Changes in electrolyte levels
• Increased sensitivity to sunlight

Less common but important to monitor:

• High blood sugar levels
• Kidney failure
• Difficulties with sexual performance (e.g., erectile dysfunction)

When taking chlorothiazide, it's important to be aware of potential interactions with other medications and substances:

• Nonsteroidal Anti-Inflammatory Drugs (NSAIDs): Medications like Ibuprofen and Naproxen can reduce the effectiveness of chlorothiazide in lowering blood pressure and promoting fluid loss.

• Other Antihypertensive Medications: Combining chlorothiazide with other blood pressure-lowering drugs may enhance their effects, potentially leading to excessively low blood pressure.

• Cholestyramine and Colestipol: These substances can bind to chlorothiazide in the digestive tract, decreasing its absorption and effectiveness.

• Corticosteroids and Adrenocorticotropic Hormone (ACTH): Using these with chlorothiazide may intensify electrolyte imbalances, particularly low potassium levels.

• Lithium: Chlorothiazide can decrease the removal of lithium from the body, increasing the risk of lithium toxicity.

• Alcohol, Barbiturates, and Narcotics: These substances can enhance the risk of low blood pressure when taken with chlorothiazide.

• Antidiabetic Medications: Chlorothiazide may affect blood sugar levels, necessitating adjustments in diabetes medications.

• Skeletal Muscle Relaxants: Chlorothiazide can increase the responsiveness to certain muscle relaxants, potentially leading to prolonged muscle relaxation.

• Pressor Amines (e.g., Norepinephrine): The response to these substances may be decreased when used with chlorothiazide, though this effect is generally not significant enough to preclude their use.

Always inform your healthcare provider about all medications, supplements, and substances you are using to ensure safe and effective treatment with chlorothiazide.