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The following safety information outlines important considerations and warnings associated with the use of this medication. Please read carefully and consult your healthcare provider if you have any questions or concerns.

• Serious Allergic Reactions: Although uncommon, trimethoprim can cause serious allergic reactions, including potentially life-threatening conditions such as severe skin reactions and anaphylaxis. If you have a known allergy to antibiotics, inform your healthcare provider to confirm that trimethoprim is safe for you. Seek immediate medical attention if you experience symptoms such as hives, rash, redness, peeling or blistering skin, swelling of the lips or tongue, or difficulty breathing after taking the medication.

• C. difficile Infection Risk: Use of antibiotics like trimethoprim can increase the risk of infection with Clostridioides difficile (C. diff), a bacterium that causes diarrhea, which may become life-threatening. This occurs because antibiotics can alter the balance of normal bacteria in the digestive tract, allowing C. diff to proliferate.

• Risk of Drug-Resistant Bacteria: It is crucial to take trimethoprim exactly as prescribed. Deviating from the prescribed course, either by shortening or extending the duration, or using it for non-prescribed conditions, can increase the risk of developing drug-resistant bacteria. This can lead to severe infections that are challenging to treat.

• Contraindications: Trimethoprim should not be used in cases of anemia caused by folic acid deficiency. If you have this condition, consult your healthcare provider before starting the medication, as it may pose serious health risks.

Adhering to this safety information will help ensure the appropriate and safe use of trimethoprim. Always discuss any concerns or questions with your healthcare provider.

When taking this medication, you may experience some common side effects such as diarrhea, nausea, vomiting, stomach upset, rash, itching, and headache. While these effects are usually mild and may subside on their own, if they persist or become bothersome, it is advisable to consult your healthcare provider. Other less common side effects include a loss of appetite, changes in taste, and increased sensitivity to sunlight, which may lead to sunburn.

In rare cases, the medication can lead to more serious side effects, such as severe allergic reactions. Symptoms may include rash, itching, swelling (especially of the face, tongue, or throat), severe dizziness, and trouble breathing. Additionally, there is a potential risk for a serious intestinal condition caused by C. difficile, characterized by persistent diarrhea, abdominal pain, and blood or mucus in the stool. Immediate medical attention is necessary if these symptoms occur.

Prolonged use of the medication may lead to oral thrush or yeast infections. Look out for white patches in the mouth or changes in vaginal discharge, and contact your doctor if these arise. Severe side effects, though rare, can include seizures and signs of liver disease like persistent nausea, vomiting, dark urine, or yellowing of the skin or eyes. Should any of these serious symptoms manifest, seek medical help without delay.

Trimethoprim can interact with other medications, leading to potential complications. It is important to inform your doctor and pharmacist about all medications and supplements you are taking, whether they are prescribed, over-the-counter, or herbal.

One significant interaction is with the medication Dofetilide, which is generally advised against using with trimethoprim due to possible serious interactions. Additionally, trimethoprim may affect lab test results, especially those measuring kidney function and methotrexate levels, potentially leading to inaccurate conclusions. Therefore, ensure that all healthcare providers are aware you are using trimethoprim.

Other medications that may interact with trimethoprim include levomethadyl and Methenamine, which might require changes to your treatment plan. Furthermore, a long list of medications, such as Amiodarone, Azathioprine, and Warfarin, among others, might require dose adjustments or close monitoring if used concurrently with trimethoprim to manage side effects effectively. Always consult your healthcare provider to navigate these interactions safely.