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The following safety information highlights important warnings and precautions associated with the use of clonidine. It is crucial to understand these risks and consult your healthcare provider if you have any questions or concerns.

• Withdrawal Risk: Abruptly discontinuing clonidine can result in severe side effects, including elevated blood pressure, nervousness, agitation, headaches, and tremors. In some cases, these symptoms may become life-threatening, especially if you are on a higher dose or using beta-blockers like carvedilol (Coreg) concurrently. Always consult your healthcare provider before stopping clonidine, as they can assist in gradually reducing your dose.

• Drowsiness and Dizziness: Clonidine may cause sleepiness or dizziness, increasing the likelihood of falls. This risk is amplified if you consume alcohol or use medications that induce drowsiness, such as opioids, sleep aids, or certain antidepressants. Avoid driving or operating machinery after taking clonidine. Seek medical attention if you experience lightheadedness, confusion, dizziness, or excessive drowsiness.

• Heart Complications: Clonidine has been associated with heart rhythm disturbances. The risk is greater if you are taking other medications that slow heart rate, such as diltiazem (Cardizem) or verapamil. Your healthcare provider may monitor your heart rate while you are on clonidine with these medications. Contact your healthcare provider if you often feel dizzy, fatigued, or short of breath after using clonidine.

• Skin Reactions (Clonidine Patches): Notify your healthcare provider immediately if you experience skin reactions, such as rashes or blisters, after applying a clonidine patch. Depending on the severity of the reaction, your provider may recommend an alternative medication.

It is crucial to follow these guidelines to minimize risks while using clonidine effectively. Always communicate with your healthcare provider for personalized advice and monitoring.

Common side effects:

• Dry mouth
• Drowsiness
• Dizziness
• Constipation
• Feeling low in energy

Less common but important to monitor:

• Itchy rashes
• Blisters
• Headaches
• Changes in skin color
• Skin swelling
• Burning or pain with a clonidine patch
• Nausea
• Nervousness
• Difficulty sleeping

Serious side effects:

• Fainting
• Slow or irregular heartbeat
• Mental or mood changes
• Severe dizziness
• Breathing difficulties

Interactions with high risk of serious adverse effects and should be avoided:

• Acebutolol
• Amitriptyline
• Atenolol
• Bisoprolol
• Imipramine
• Metoprolol
• Propranolol
• Verapamil
• Ceritinib
• Crizotinib
• Iobenguane I 131
• Macimorelin

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Cyclosporine
• Fluphenazine
• Mepivacaine
• Naloxone
• Yohimbine

Interactions with low risk that usually do not require a change in therapy:

• Alcohol
• Marijuana (cannabis)
• Cetirizine
• Diphenhydramine
• Alprazolam
• Diazepam
• Zolpidem
• Muscle relaxants
• Codeine
• Cough-and-cold products
• Diet aids
• NSAIDs such as ibuprofen/naproxen