Methyldopa

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Methyldopa is a medication used to manage high blood pressure (hypertension), either on its own or in combination with other drugs. By lowering blood pressure, it helps in preventing serious health issues such as strokes, heart attacks, and kidney problems. This medication belongs to the alpha-2 adrenergic receptor agonists class and works by signaling the brain to relax blood vessels, facilitating easier blood flow. Methyldopa is particularly favored for managing high blood pressure during pregnancy. Due to its short duration in the body, it needs to be taken multiple times a day. Some common side effects may include drowsiness, headaches, and a feeling of weakness. Always consult with a healthcare professional before starting or changing any medication.
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250MG, Methyldopa (30 Tablets)

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CVS

$246.40

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$5.00

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$9.75

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$77.50

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$236.30

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Methyldopa dosage forms

The average cost for 30 Tablets of Methyldopa at 250MG is $5 with a free coupon. This is 99% off the average retail price of $454.72
DosageQuantityPrice fromPer unit
250MG30 Tablets$5$0.17
500MG30 Tablets$1.01$0.03

Methyldopa Warnings

This document outlines critical safety information and warnings associated with the use of methyldopa. Please read the following details carefully, and consult your healthcare provider if you have any questions or concerns.

  • Liver Concerns: Methyldopa can occasionally cause severe liver issues, and in rare instances, these may be life-threatening. Individuals with existing liver conditions should avoid this medication. Regular follow-up appointments and blood tests are crucial to monitor liver function. Seek immediate medical attention if you notice symptoms like unusual vomiting, light-colored stools, dark urine, abdominal pain, or yellowing of the skin and eyes.

  • Hemolytic Anemia: A rare but serious condition called hemolytic anemia can occur with prolonged methyldopa use. This condition involves the rapid destruction of red blood cells and is potentially life-threatening. It is more likely to develop between six to twelve months of continuous use. Regular blood tests are recommended to detect early signs.

  • Low Blood Cell Count: Methyldopa can sometimes reduce white blood cells and platelets, which are crucial for fighting infections and aiding blood clotting. Routine blood tests are necessary to ensure these levels remain normal. Any changes in blood cell counts are typically reversible after discontinuing the medication.

Contraindications:

  • Avoid using methyldopa if you have liver problems or are currently taking monoamine oxidase inhibitors (MAOIs), as these situations may pose significant health risks. Always consult with your healthcare provider before starting methyldopa if these conditions apply to you.

Methyldopa Side Effects

Common side effects:

  • dizziness
  • lightheadedness
  • drowsiness
  • headache
  • stuffy nose
  • weakness
  • dry mouth
  • temporary sleepiness

Less common but important to monitor:

  • nausea
  • vomiting
  • gas
  • swelling
  • muscle pain
  • "pins and needles" sensation
  • changes in sexual function
  • trouble with erections
  • decreased sex drive
  • weight gain
  • depression
  • mood changes

Serious side effects:

  • symptoms of liver damage
  • severe stomach pain
  • persistent nausea or vomiting
  • pale stools
  • dark urine
  • yellowing of the skin or eyes
  • symptoms indicating a breakdown of red blood cells
  • unusual tiredness
  • chills
  • paleness
  • fainting
  • very serious allergic reactions
  • rash
  • severe dizziness
  • trouble breathing

Methyldopa Interactions

Interactions with high risk of serious adverse effects and should be avoided:

  • MAO inhibitors (isocarboxazid, linezolid, moclobemide, phenelzine, procarbazine, rasagiline, selegiline, tranylcypromine)
  • Brofaromine
  • Clorgyline
  • Furazolidone
  • Iproniazid
  • Lazabemide
  • Nialamide
  • Pargyline
  • Toloxatone

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

  • Entacapone
  • Iobenguane I 131
  • Pseudoephedrine

Interactions with low risk that usually do not require a change in therapy:

  • Alprenolol
  • Bisoprolol
  • Ferric Ammonium Citrate
  • Haloperidol
  • Iron
  • Phenylpropanolamine
  • Sotalol
  • Timolol
Methyldopa FAQs
Is methyldopa an alpha or beta blocker?

Methyldopa is an alpha-2 adrenergic agonist, not an alpha or beta blocker. It works by stimulating alpha-2 receptors in the central nervous system, which leads to a decrease in sympathetic outflow and a reduction in blood pressure.

Methyldopa is classified as an antihypertensive medication, specifically a centrally acting alpha-2 adrenergic agonist.

Methyldopa is commonly used in pregnancy to manage high blood pressure. It is considered a safe antihypertensive medication for pregnant women, as it has a long history of use and does not appear to harm the developing fetus. Methyldopa works by relaxing blood vessels, which helps to lower blood pressure and improve blood flow.

Methyldopa can cause several side effects. Common ones include drowsiness, headache, weakness, and dizziness. Some individuals may experience dry mouth, nasal congestion, or gastrointestinal issues such as nausea or diarrhea. In rare cases, it can lead to more serious side effects like liver dysfunction, hemolytic anemia, or depression. It is important for individuals to consult their healthcare provider if they experience any concerning symptoms.

Labetalol and methyldopa are both medications used to manage high blood pressure, but they work in different ways. Labetalol is a combined alpha and beta-blocker, which means it reduces blood pressure by blocking certain receptors in the heart and blood vessels, leading to decreased heart rate and dilation of blood vessels. Methyldopa, on the other hand, is a centrally acting alpha-2 adrenergic agonist. It lowers blood pressure by stimulating receptors in the brain that reduce nerve signals to the blood vessels, causing them to relax. Additionally, methyldopa is often used in managing hypertension during pregnancy.