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This document outlines critical safety information and warnings associated with the use of methyldopa. Please read the following details carefully, and consult your healthcare provider if you have any questions or concerns.

• Liver Concerns: Methyldopa can occasionally cause severe liver issues, and in rare instances, these may be life-threatening. Individuals with existing liver conditions should avoid this medication. Regular follow-up appointments and blood tests are crucial to monitor liver function. Seek immediate medical attention if you notice symptoms like unusual vomiting, light-colored stools, dark urine, abdominal pain, or yellowing of the skin and eyes.

• Hemolytic Anemia: A rare but serious condition called hemolytic anemia can occur with prolonged methyldopa use. This condition involves the rapid destruction of red blood cells and is potentially life-threatening. It is more likely to develop between six to twelve months of continuous use. Regular blood tests are recommended to detect early signs.

• Low Blood Cell Count: Methyldopa can sometimes reduce white blood cells and platelets, which are crucial for fighting infections and aiding blood clotting. Routine blood tests are necessary to ensure these levels remain normal. Any changes in blood cell counts are typically reversible after discontinuing the medication.

Contraindications:

• Avoid using methyldopa if you have liver problems or are currently taking monoamine oxidase inhibitors (MAOIs), as these situations may pose significant health risks. Always consult with your healthcare provider before starting methyldopa if these conditions apply to you.

Common side effects:

• dizziness
• lightheadedness
• drowsiness
• headache
• stuffy nose
• weakness
• dry mouth

• temporary sleepiness

  Less common but important to monitor:

• nausea
• vomiting
• gas
• swelling
• muscle pain
• "pins and needles" sensation
• changes in sexual function
• trouble with erections
• decreased sex drive
• weight gain
• depression

• mood changes

  Serious side effects:

• symptoms of liver damage
• severe stomach pain
• persistent nausea or vomiting
• pale stools
• dark urine
• yellowing of the skin or eyes
• symptoms indicating a breakdown of red blood cells
• unusual tiredness
• chills
• paleness
• fainting
• very serious allergic reactions
• rash
• severe dizziness
• trouble breathing

When taking this medication, be aware of potential interactions with other drugs and supplements. It's important to inform your doctor and pharmacist about all other medications or supplements you are using, including prescriptions, over-the-counter drugs, vitamins, and herbal products.

Interactions to Avoid:

• MAO inhibitors such as isocarboxazid, linezolid, moclobemide, phenelzine, procarbazine, Rasagiline, Selegiline, and Tranylcypromine should not be taken with this medication as it can lead to a serious, possibly fatal, reaction. Most MAO inhibitors should not be used for two weeks before starting or stopping this medication.

Use with Caution:

• Certain drugs may increase drowsiness when used with this medication. These include alcohol, cannabis, antihistamines (e.g., Cetirizine, diphenhydramine), sleep or anxiety medications (e.g., Alprazolam, Diazepam, Zolpidem), muscle relaxants, and opioid pain relievers (e.g., codeine).
• Products such as cough-and-cold medicines, diet aids, or NSAIDs like Ibuprofen and Naproxen may raise blood pressure. Consult your pharmacist on their safe use.

Other Considerations:

• This drug can interfere with specific lab tests, potentially causing inaccurate results. Ensure that all healthcare providers and lab personnel are aware you're using this medication.

Your healthcare provider might adjust your medication regimen to prevent or manage these interactions safely. Always follow your doctor's guidance regarding medication use.