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Naproxen, a nonsteroidal anti-inflammatory drug, carries certain risks and precautions that should be carefully considered. Below are important safety and warning details for users of this medication:

• Increased Risk of Heart Attack or Stroke: Naproxen may rarely elevate the risk of heart attack or stroke, particularly with long-term use. This risk is heightened for older adults and individuals with existing heart conditions or factors such as smoking, high blood pressure, diabetes, or a family history of heart disease. Avoid using this drug immediately before or after coronary artery bypass graft (CABG) surgery.

• Potential for Gastrointestinal Bleeding: There is a rare risk of serious, potentially fatal bleeding from the stomach or intestines, which can occur without warning. Older adults are particularly susceptible.

• Urgent Medical Attention: Discontinue naproxen and seek immediate medical assistance if you experience any of these serious symptoms: persistent stomach or abdominal pain, black or tarry stools, vomit resembling coffee grounds, chest, jaw, or left arm pain, shortness of breath, unusual sweating, confusion, weakness on one side of the body, difficulty speaking, or sudden changes in vision.

• Consultation with Healthcare Professionals: It is important to discuss the benefits and risks of naproxen with your doctor or pharmacist before starting the medication, especially if you have pre-existing health conditions.

By understanding these safety considerations, users can better manage the risks associated with naproxen while benefiting from its intended effects.

While using this medication, you might experience mild side effects such as an upset stomach, nausea, heartburn, headache, drowsiness, or dizziness. These are common and usually temporary, but if they persist or worsen, it's important to consult a healthcare professional. Additionally, this medication could lead to an increase in blood pressure, so monitoring your levels regularly is advisable.

There are also more serious side effects to be aware of. Seek immediate medical attention if you notice easy bruising or bleeding, trouble swallowing, changes in hearing like ringing in the ears, mood swings, or signs of kidney issues such as changes in urine output. Other serious symptoms include vision changes or symptoms indicative of heart failure, such as swollen ankles or feet, unusual fatigue, or sudden weight gain.

In rare cases, this drug can cause severe liver disease, which can be life-threatening. Seek urgent medical attention if you experience persistent nausea or vomiting, loss of appetite, stomach or abdominal pain, yellowing of the eyes or skin, or dark urine. Although a severe allergic reaction is rare, be alert for symptoms like fever, swollen lymph nodes, rash, itching, swelling of the face, tongue, or throat, severe dizziness, or difficulty breathing, and get medical help immediately.

This is not an exhaustive list of side effects. If you notice other unusual symptoms, contact your healthcare provider for further advice.

Certain medications can interact with this drug, potentially altering its effects. These include blood pressure medications like Aliskiren, ACE inhibitors (e.g., Captopril, Lisinopril), and angiotensin II receptor blockers (e.g., Losartan, Valsartan), as well as Cidofovir, corticosteroids (e.g., Prednisone), Lithium, and diuretics such as Furosemide. This drug can also increase bleeding risk when combined with other medications that thin the blood, such as Clopidogrel, Dabigatran, Enoxaparin, and Warfarin.

Be cautious with over-the-counter pain relievers and fever reducers, as many contain Aspirin or NSAIDs like Celecoxib, Ibuprofen, or Ketorolac, which are similar to Naproxen and may heighten the risk of side effects. If you're taking low-dose aspirin (81-162 mg daily) to prevent heart attacks or strokes, continue as advised by your doctor, but be aware that naproxen can reduce aspirin's effectiveness in this regard. Discuss with your doctor the risks and benefits and consider alternative options for pain and fever management.

Additionally, this medication might interfere with certain laboratory tests, leading to inaccurate results. Ensure that all healthcare providers and lab personnel are informed that you are taking this medication.