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This document outlines crucial safety information and warnings related to the use of Gocovri (amantadine). It's important to read through these details carefully and consult your healthcare provider if you have any questions or concerns.

• Daytime Sleepiness and Activities: Gocovri can cause unexpected sleepiness, potentially leading to accidents during activities such as driving or operating machinery. Discuss with your provider if you have a history of sleep disorders or take medications that cause drowsiness. Avoid alcohol, as it can exacerbate drowsiness. Refrain from activities requiring full alertness until you understand how Gocovri affects you. Report any incidents of falling asleep during normal activities to your healthcare provider immediately.

• Suicidal Thoughts or Behavior: This medication may increase the risk of suicidal thoughts or actions, especially in individuals with a history of depression. Monitor for any changes in mood or behavior, particularly at the start of treatment or when adjusting doses, and report any concerns to your provider promptly.

• Mood Changes and Hallucinations: Gocovri may lead to hallucinations or mood alterations, particularly in those with a history of psychosis or upon abrupt discontinuation of the drug. Inform your provider if you have any history of mental health issues before starting treatment.

• Low Blood Pressure and Dizziness: The medication can cause a drop in blood pressure, increasing the risk of fainting. Discuss your medical history and current medications with your provider to ensure Gocovri is safe for you, especially if you consume alcohol or are on a high dose.

• Withdrawal Symptoms: Abruptly stopping or reducing the dose of Gocovri can cause withdrawal symptoms similar to neuroleptic malignant syndrome, a severe condition characterized by high fever, confusion, and muscle stiffness. It can also worsen Parkinson’s symptoms. Do not discontinue or adjust your dose without consulting your provider for a safe cessation plan.

• Impulsive Behaviors: Gocovri may lead to impulsive behaviors such as excessive spending, gambling, or eating. If these behaviors negatively impact your life, inform your provider. Reducing the dose or discontinuing the medication may alleviate these urges. Your provider might inquire about any new behaviors during your visits.

• Contraindication: Gocovri should not be used in individuals with end-stage kidney disease. If this applies to you, discuss with your healthcare provider before starting the medication.

Please prioritize these safety considerations and maintain open communication with your healthcare provider for the best outcomes.

When taking this medication, some common side effects may include dizziness, dry mouth, and lightheadedness, which can increase the risk of falls. To manage dry mouth, you can suck on sugarless candy or ice chips and drink plenty of water. Constipation, blurred vision, and nausea are also possible, but these are generally mild and manageable. If you experience swelling in the arms and legs, headache, or trouble sleeping, it is advisable to monitor these symptoms and consult a healthcare provider if they persist.

More concerning side effects that require prompt medical attention include purplish-red blotchy spots on the skin, vision changes, difficulty urinating, and unusual strong urges such as increased gambling or spending. Mood changes, such as anxiety, depression, or hallucinations, should also be reported to a healthcare provider. Muscle spasms and repetitive movements, along with strange dreams, might occur.

In rare cases, serious side effects such as seizures, neuroleptic malignant syndrome (characterized by high fever and muscle stiffness), and suicidal thoughts or behaviors need immediate medical intervention. There is also a risk of falling asleep suddenly during daily activities, which can be dangerous. A severe allergic reaction, though rare, may involve symptoms like rash, severe dizziness, or trouble breathing, and requires urgent care. If you encounter any of these severe symptoms, seek medical help right away.