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Fluorouracil (Efudex) topical is a medication with specific safety considerations that are crucial for users to understand. Please ensure you thoroughly review the following information and consult your healthcare provider if you have any questions or concerns:

• Avoid Sensitive Areas: Do not apply the medication on sensitive skin areas or near mucous membranes, such as around the eyes, mouth, or nose, as this increases the risk of skin damage.

• Do Not Cover Treated Areas: Refrain from using bandages or dressings over areas where the medication has been applied. Covering these areas can increase absorption, leading to more severe skin-related side effects.

• Sun Exposure Warnings: The use of fluorouracil can lead to serious skin reactions when exposed to ultraviolet (UV) light, causing painful peeling or blistering. Avoid sun lamps, tanning beds, and try to minimize direct sunlight exposure. If you must be outdoors, consult your dermatologist about using sunscreen and wearing protective clothing, such as hats and long-sleeved shirts.

• Pregnancy Warning: This medication can cause serious harm to an unborn child, including birth defects and miscarriage. If you are pregnant or planning to become pregnant, inform your dermatologist immediately. This warning is particularly important for females of childbearing age.

• Rare Toxicity Reaction: In rare cases, individuals with dihydropyrimidine dehydrogenase (DPD) deficiency may experience severe reactions, including stomach pain, bloody diarrhea, vomiting, fever, and inflammation in the mouth, stomach, and intestines. If you have this deficiency, discuss the risks with your healthcare provider.

• Contraindications: Do not use this medication if you are currently pregnant or have a known DPD deficiency, as it may pose serious health risks. Always consult your healthcare provider if these conditions apply to you.

In case of any adverse reactions or overdose, seek immediate medical attention. These guidelines are designed to ensure your safety while using fluorouracil (Efudex) topical.

When using this medication, you may experience some common side effects at the application site, including skin irritation, a burning or stinging sensation, redness, dryness, or itchiness. These effects are generally mild and temporary. If they persist or become bothersome, consult your healthcare provider for guidance. Additionally, some individuals may notice temporary hair loss, an abnormal taste in the mouth, or trouble sleeping.

There are also less common side effects that warrant attention, such as darkening of the skin, soreness, or blistering. If you experience skin tenderness, open sores, or a rash, it's important to reach out to your healthcare provider, especially if these symptoms are severe.

More serious side effects, though rare, include stomach pain, bloody diarrhea, vomiting, or signs of infection like persistent sore throat, fever, or chills. If you encounter these or symptoms of a severe allergic reaction—such as rash, severe dizziness, swelling (especially of the face, tongue, or throat), or difficulty breathing—seek immediate medical attention. While these serious reactions are uncommon, they require prompt intervention. Always keep your healthcare provider informed of any side effects you experience with this medication.