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The following safety guidelines detail the potential risks and necessary precautions when using Valchlor (mechlorethamine). Please read them thoroughly and consult your healthcare provider if you have any questions or concerns.

• Accidental Exposure to Eyes, Nose, or Mouth: Always wash your hands immediately after applying Valchlor to avoid accidental contact with your eyes, nose, or mouth, which can lead to injuries.

• Risk of Transference to Others: Exercise caution during and after the application of Valchlor, as the medication can transfer to other people's skin. If someone else comes into contact with the medication, they should wash the affected area with soap and water for at least 15 minutes and remove any contaminated clothing. Accidental exposure can result in skin inflammation, injuries to the eyes, nose, or mouth, and may increase the risk of certain skin cancers.

• Dermatitis (Skin Irritation): Skin irritation or inflammation is a common side effect of Valchlor, especially when applied to sensitive areas such as the face, genital area, anus, or skin folds. Should you experience redness, swelling, itching, blisters, ulcers, or infections, contact your healthcare team. Your oncologist may advise reducing the frequency of application.

• Non-Melanoma Skin Cancer: A small number of patients using Valchlor have developed non-melanoma skin cancer, sometimes in areas not treated with the medication and possibly linked to previous treatments. Your oncologist will monitor your skin for any new lesions during follow-ups. Report any abnormal skin changes immediately.

• Risk to Unborn Babies: Valchlor may pose a risk to unborn babies. Anyone who can become pregnant should use effective birth control during treatment. Barrier methods, like condoms or diaphragms, are recommended to prevent exposure to the genital area. Notify your healthcare provider immediately if you become pregnant during treatment.

• Breastfeeding Warning: It is advised not to breastfeed while using Valchlor, as the medication might transfer to a baby through skin contact. While there is no specific research on its effects on breastfed children, potential harm exists. Consult your child's pediatrician for alternative nutrition and feeding options.

When using this medication, some individuals may experience mild side effects, including skin irritation, itching, blisters, redness, pain, swelling, tenderness, and darkening of the skin at the application site. These effects are common and typically not serious, but if they persist or worsen, it is advisable to consult your healthcare provider for guidance.

In some instances, users may develop low blood counts or bacterial skin infections. If you encounter these issues, or if you experience skin ulcers or blisters, it is important to reach out to a healthcare professional. Additionally, some people have reported eye, mouth, or nose injuries due to accidental exposure, leading to symptoms like pain, blurry vision, sensitivity to light, burning, and redness.

Although rare, there are serious side effects to be mindful of. These include easy bruising or bleeding, signs of infection such as skin ulcers with pus, fever, and chills. Very rarely, individuals may develop non-melanoma skin cancer or notice new skin lesions or unusual changes. Immediate medical attention is necessary if you observe any of these symptoms.

A very serious allergic reaction is also rare, but should you experience symptoms like a rash, significant swelling (particularly of the face, tongue, or throat), severe dizziness, or difficulty breathing, seek emergency medical help immediately. It is important to be aware of these potential side effects and contact your healthcare provider if you have any concerns or notice other effects not listed here.