Estriol

Drug Details

Estriol is one of the three primary estrogens produced in the human body, alongside estradiol and estrone. Unlike its counterparts, estriol is considered a weaker estrogen and is produced in significant amounts primarily during pregnancy. During this time, it plays a crucial role in maintaining the uterine lining and supporting fetal development. In non-pregnant individuals, estriol levels are typically low. Medically, estriol is utilized in hormone replacement therapy to alleviate menopausal symptoms such as hot flashes, night sweats, and vaginal dryness. It is available in various forms, including oral tablets, vaginal creams, and suppositories. Due to its weaker estrogenic activity, estriol is often considered to have a more favorable safety profile compared to stronger estrogens, though it may still carry risks such as stimulating uterine tissue growth. Therefore, its use should be carefully managed under medical supervision.