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Warfarin has the potential to cause severe, and potentially life-threatening, bleeding. This risk is heightened when beginning treatment or if an excessive amount of warfarin is consumed.

To minimize the risk of bleeding:

• Your healthcare provider will closely monitor your condition and regularly review your lab results, specifically the International Normalized Ratio (INR) test, to ensure the correct dosage of warfarin.
• Attend all scheduled medical and laboratory appointments without fail.
• Immediately inform your doctor if you observe any symptoms indicative of serious bleeding.

It is crucial to adhere to these precautions to ensure your safety while using warfarin.

When taking this medication, you might experience mild side effects such as nausea, loss of appetite, or stomach/abdominal pain. These are generally not serious, but if they persist or worsen, consult your healthcare provider. Most individuals using this medication do not encounter severe side effects, which can be reassuring.

However, this drug can cause serious bleeding if it significantly impacts your blood clotting proteins, indicated by high INR lab results. Even after stopping the medication, the bleeding risk may persist for up to a week. Be alert for serious bleeding signs such as frequent or persistent nosebleeds, unusual pain or swelling, easy bruising, prolonged bleeding from cuts, heavy menstrual flow, pink or dark urine, coughing up blood, bloody vomit, severe headaches, dizziness, unusual tiredness, bloody stools, chest pain, shortness of breath, or difficulty swallowing, and seek medical attention immediately.

Report any severe effects like persistent nausea or vomiting, severe stomach pain, or yellowing of the skin or eyes to your healthcare provider. Rarely, the drug can cause very serious issues involving small blood clots, which could result in severe tissue damage. This is more likely in individuals with specific blood conditions. Seek urgent care if you notice red or purplish skin patches, changes in urine output, vision changes, confusion, trouble speaking, or weakness on one side of the body.

Allergic reactions to this medication are rare but can be severe. If you experience a rash, swelling (especially of the face, tongue, or throat), severe dizziness, or trouble breathing, get medical help immediately. If you observe any side effects not listed here, contact your healthcare provider.

Warfarin can interact with numerous medications, including prescription and over-the-counter drugs, as well as vitamins and herbal supplements. These interactions can affect the medication whether it is taken orally, applied to the skin, or used inside the vagina or rectum. Warfarin interactions often lead to changes in its "blood-thinning" effects, either increasing or decreasing its effectiveness. To avoid serious bleeding or clotting issues, your healthcare provider should monitor you closely. It's crucial to inform your doctor or pharmacist about any changes to your medicines, vitamins, or supplements while you're on warfarin.

Some specific products that may interact with warfarin include Imatinib, marijuana (cannabis), Dronabinol, Mifepristone, and other drugs that can lead to bleeding or bruising, such as other anticoagulants like apixaban or Dabigatran. Additionally, Aspirin, aspirin-like drugs (salicylates), and nonsteroidal anti-inflammatory drugs (NSAIDs) like Ibuprofen, Naproxen, and Celecoxib, may have similar effects to warfarin and raise the risk of bleeding. Always check the labels of all medications, including topical treatments like pain-relieving creams, for NSAIDs or salicylates. Discuss alternative pain/fever medications, such as Acetaminophen, with your doctor. If your doctor has advised you to take low-dose aspirin for heart attack or stroke prevention (typically 81-162 milligrams daily), continue doing so unless instructed otherwise. For further guidance, consult your doctor or pharmacist.

Warfarin may also interfere with certain laboratory tests, such as those measuring theophylline levels, potentially leading to inaccurate results. Ensure that all healthcare professionals and lab personnel are aware that you are taking warfarin.