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The following safety information outlines key warnings related to the use of Januvia (sitagliptin). It is important to carefully consider these potential risks and consult your healthcare provider with any concerns or questions.

• Pancreatitis Risk: Although rare, some individuals using Januvia (sitagliptin) have reported inflammation of the pancreas, known as pancreatitis. While the direct link to the medication is uncertain, it is crucial to discontinue use and contact your healthcare provider immediately if you notice symptoms such as upper stomach pain, fever, nausea, or vomiting.

• Heart Failure Concerns: While it is not definitively established that Januvia (sitagliptin) increases the risk of heart failure, similar medications have been associated with this condition. Discuss any existing heart or kidney conditions with your healthcare provider before beginning treatment. Seek immediate medical attention if you experience symptoms like difficulty breathing, fatigue, bodily swelling, or unexpected weight gain.

• Kidney Health: There have been reports of sudden kidney injury in some individuals taking Januvia (sitagliptin), occasionally necessitating dialysis. Your healthcare provider may conduct blood tests to monitor kidney function before and during treatment, especially if you have pre-existing kidney issues. Notify your provider if you notice a decrease in urination.

• Allergic Reactions: Rarely, Januvia (sitagliptin) can trigger severe allergic reactions, particularly in individuals with a history of allergies to DPP-4 inhibitors or "gliptins," such as Tradjenta (linagliptin) or Nesina (alogliptin). Symptoms may include rash, skin blistering, swelling, breathing difficulties, and dizziness. If these occur, stop the medication and seek medical assistance immediately.

• Joint Pain: Some individuals on Januvia (sitagliptin) or similar diabetes medications have experienced significant joint pain, which can occur at any time during treatment. The pain typically subsides after discontinuation. If you experience joint discomfort, consult your healthcare provider promptly.

• Severe Skin Reactions: In rare cases, users may develop an itchy, blistering rash known as bullous pemphigoid. These symptoms usually resolve upon stopping the medication. Report any itchy skin, blistering, or sores to your healthcare provider immediately and discontinue use.

There are no specific contraindications listed for Januvia (sitagliptin). However, it is vital to discuss your full medical history with your healthcare provider to ensure this medication is appropriate for you.

Sitagliptin is a medication that can lead to various side effects, some more common and mild, while others are rare but serious. Commonly, individuals may experience symptoms similar to a cold, such as a runny nose and sore throat, affecting about 5% of users. Headaches have also been reported and typically do not require urgent medical attention unless persistent or worsening.

Low blood sugar, or hypoglycemia, is a potential risk, especially when sitagliptin is used alongside other diabetes medications. Symptoms to watch for include sudden sweating, shaking, fast heartbeat, hunger, blurred vision, dizziness, or tingling in the hands or feet. It is advisable to carry glucose tablets, or quickly consume a sugary food or drink if such symptoms arise. High blood sugar, or hyperglycemia, may present as increased thirst or urination and should be reported to a healthcare provider.

Serious, yet rare, side effects necessitate immediate medical attention. These include signs of pancreatitis, such as severe stomach pain, nausea, or vomiting. Additionally, severe allergic reactions, characterized by rash, swelling, or difficulty breathing, require urgent care. Sudden kidney problems may manifest as changes in urination, swelling in the legs or ankles, fatigue, or confusion, and should be addressed promptly.

While a severe allergic reaction is rare, any signs such as rash, itching, swelling, severe dizziness, or trouble breathing require immediate medical intervention. If any other side effects are noticed, consulting a healthcare professional is recommended to ensure safety and appropriate management.

When taking Januvia (Sitagliptin), it is crucial to inform your doctor and pharmacist about any other medications or supplements you are using, including those obtained over-the-counter, as well as vitamins and herbal products. This ensures safe management of potential drug interactions.

Beta-blockers, such as metoprolol, Propranolol, and Timolol (used in glaucoma eye drops), can interfere with the typical awareness of a rapid or pounding heartbeat associated with low blood sugar (hypoglycemia). However, they do not alter other symptoms like dizziness, hunger, or sweating. It is important to monitor your blood sugar levels closely and discuss any significant changes with your healthcare provider, who may need to adjust your diabetes management plan, including your medication, exercise, or diet.

Additionally, Januvia may interact with a range of other medications. Some interactions might increase the risk of side effects but could still be necessary for your treatment, requiring a possible adjustment of dosages or usage frequency by your doctor. Medications that may interact include various antibiotics and antidiabetic drugs such as Acarbose, Metformin, and Glimepiride, among others. If you are prescribed Januvia alongside any of these medications, your healthcare provider will carefully assess and manage these interactions for your safety.