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When taking sitagliptin, be aware that it can interact with other diabetes medications, potentially causing low blood sugar. Symptoms of low blood sugar include sweating, shaking, rapid heartbeat, hunger, blurred vision, dizziness, or tingling in the hands and feet. To manage this, keep glucose tablets or gel handy. If unavailable, consuming sugar-rich foods or drinks can help. Consult a healthcare professional for advice if you experience low blood sugar, especially if you've been drinking alcohol, exercising heavily, or not eating enough.

High blood sugar symptoms such as increased thirst and urination should also be monitored. Contact a healthcare provider if they occur, as medication, diet, or exercise adjustments might be necessary. Serious side effects to watch for include signs of kidney issues (changes in urine output), joint pain, skin blisters, or signs of heart failure like shortness of breath, swollen ankles, unusual tiredness, or sudden weight gain. Seek immediate medical attention for symptoms of pancreatitis, such as persistent nausea, vomiting, loss of appetite, or severe pain in the stomach, abdomen, or back.

Though rare, serious allergic reactions can occur, characterized by rash, itching, swelling (especially of the face, tongue, or throat), severe dizziness, or difficulty breathing. Seek emergency medical help if these symptoms appear. This summary does not cover all possible side effects, so if you notice any other unusual reactions, consult your healthcare provider for guidance.