Saxagliptin

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saxagliptin

Saxagliptin is a medication used to manage high blood sugar levels in adults with type 2 diabetes, in conjunction with a healthy diet and regular exercise. By effectively controlling blood sugar, saxagliptin helps reduce the risk of serious complications such as kidney damage, vision problems, nerve issues, limb loss, and sexual dysfunction. It may also lower the chances of experiencing a heart attack or stroke. Saxagliptin belongs to a class of drugs known as dipeptidyl peptidase-4 (DPP-4) inhibitors. It functions by blocking the DPP-4 enzyme, which breaks down incretin hormones that stimulate insulin production. This action results in prolonged insulin activity, particularly after meals, and reduces the amount of sugar produced by the liver. Saxagliptin is typically taken orally once a day. While the brand name Onglyza is no longer available, generic versions of the medication are accessible. Some potential side effects include infections and headaches. Always consult with a healthcare professional before starting any new medication.
Our Onglyza coupons are free to use. You can print the coupon, email it to yourself, or receive the Onglyza coupon via text message. To get your free discount, show the pharmacist your Onglyza savings card which has the discounted coupon price. Use our filters below to edit the prescription box to match your needs. The Onglyza prices will update based on your prescription needs. Above our Onglyza coupons, you can change the location to see pharmacy prices in other areas. Our prescription discount card will update online with the specific pharmacy costs associated with your edits. Be sure to text, email, or print the Onglyza savings card code that you need after editing the prescription box and location field. Show the discount card to your pharmacist before paying.

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2.5MG, Saxagliptin (30 Tablets)

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CVS

$132.03

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$127.29

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Albertsons

$140.46

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$154.70

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$414.07

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CVS

$132.03

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Onglyza dosage forms

The average cost for 30 Tablets of Onglyza (saxagliptin) at 2.5MG is $132.57 with a free coupon. This is 18.34% off the average retail price of $722.92
DosageQuantityPrice fromPer unit
2.5MG30 Tablets$132.57$4.42
5MG30 Tablets$43.12$1.44

Onglyza Warnings

Here are the essential safety warnings for saxagliptin (Onglyza). Please review them thoroughly and consult your healthcare provider if you have any questions or concerns.

  • Pancreatitis Risk: Although rare, some individuals have experienced inflammation of the pancreas (pancreatitis) while using saxagliptin (Onglyza). If you have a history of pancreatitis, it is unclear if this medication increases your risk. Symptoms to watch for include upper abdominal pain, fever, nausea, and vomiting. Contact your healthcare provider immediately if these symptoms occur, as discontinuation of the medication may be necessary.

  • Heart Failure Concerns: Studies have shown a potential link between saxagliptin (Onglyza) and an increased risk of hospitalization for heart failure, particularly in individuals with or at risk for heart disease. Inform your healthcare provider about your medical history to evaluate the risks versus benefits of using this medication. Seek immediate medical attention if you experience symptoms of heart failure, such as shortness of breath, irregular heartbeat, sudden weight gain, or swelling in the feet or ankles. Risk factors include a history of heart failure and kidney issues.

  • Hypoglycemia (Low Blood Sugar): Saxagliptin (Onglyza), especially when used with other diabetes medications like insulin, may cause low blood sugar, which can be life-threatening. Symptoms include shakiness, weakness, hunger, nervousness, confusion, rapid heartbeat, chills, sweating, and drowsiness. Discuss with your healthcare provider if you are concerned about low blood sugar during treatment. Risk factors include changes in diet and exercise, alcohol consumption, use of other diabetes drugs, age over 65, and liver or kidney issues.

  • Severe Joint Pain: Rarely, saxagliptin (Onglyza) can cause severe, disabling joint pain, which may occur from one day to years after starting the medication. Contact your healthcare provider immediately if you experience joint discomfort.

  • Blister Formation: Some individuals have developed large, fluid-filled blisters (bullous pemphigoid) while taking saxagliptin (Onglyza). These typically resolve with treatment and cessation of the medication. If blisters or skin sores appear, contact your healthcare provider and consider seeing a dermatologist.

  • Allergic Reactions: Although uncommon, allergic reactions to saxagliptin (Onglyza) may occur, potentially due to dye colorings in the tablets. Individuals with aspirin allergies or allergies to other DPP-4 inhibitors may be at risk. Inform your healthcare provider of all allergies before beginning treatment. Risks include allergy to Yellow No. 5 dye, aspirin, or other DPP-4 inhibitors.

Ensure to discuss any concerns or symptoms with your healthcare provider to manage your treatment safely and effectively.

Onglyza Side Effects

When taking this medication, you may experience various side effects. Common ones include upper respiratory tract infections, urinary tract infections, and headaches. These are generally mild, but if they persist or become bothersome, consult your healthcare provider for guidance.

Some individuals, especially those using this medication with other diabetes treatments, might encounter low blood sugar levels. Symptoms of this include sudden sweating, shaking, fast heartbeat, hunger, blurred vision, dizziness, or tingling in the hands or feet. To manage low blood sugar, it's advisable to carry glucose tablets or gel. If unavailable, quickly consuming sugar sources like candy or fruit juice can help. Ensure you eat regularly and avoid skipping meals to prevent these episodes.

Serious side effects, though rare, require immediate attention. Contact a healthcare professional if you notice signs of heart failure such as breathing difficulties, swelling in your ankles or feet, or unexplained weight gain. Additionally, inflammation of the pancreas is a concern, with symptoms like severe abdominal pain, persistent nausea or vomiting, and fever. Though very rare, severe allergic reactions can occur, characterized by rash, swelling of the face, tongue, or throat, or trouble breathing.

Always monitor your health and report any unusual symptoms to your doctor. This summary includes key side effects, but it's not exhaustive. If you identify other reactions not mentioned here, seek medical advice promptly.

Onglyza Interactions

Saxagliptin, also known as Onglyza, can interact with various medications, potentially altering its effectiveness or increasing the risk of side effects. Some drugs, such as azole antifungals (itraconazole, ketoconazole), nefazodone, telithromycin, and ritonavir, may impact the elimination of saxagliptin from your body, affecting how well it works.

Additionally, beta-blockers like metoprolol, propranolol, and timolol (found in some glaucoma eye drops), can mask the rapid heartbeat usually associated with low blood sugar (hypoglycemia). However, other symptoms of low blood sugar, such as dizziness, hunger, or sweating, are not affected by these medications.

A comprehensive list of possible interactions includes antibiotics like ciprofloxacin and moxifloxacin, as well as other medications like hydroxychloroquine and octreotide. While some interactions might not be recommended, they may be necessary in certain situations. Your doctor might need to adjust dosages or administration frequencies if you are taking any of these medications.

Furthermore, several medications can influence blood sugar levels, making diabetes management more challenging. These include a range of beta-blockers, sulfonylureas, and insulins. It's important to monitor your blood sugar as instructed and report any unusual symptoms to your doctor. Always consult your healthcare provider before starting, stopping, or changing any medication to ensure safe and effective diabetes management.

Onglyza FAQs
Is Onglyza the same as Januvia?

Onglyza and Januvia are not the same, but they are similar in that both are medications used to manage type 2 diabetes. They belong to the same class of drugs known as DPP-4 inhibitors, which help to lower blood sugar levels. However, they contain different active ingredients; Onglyza contains saxagliptin, while Januvia contains sitagliptin. It is important for patients to follow their healthcare provider's recommendations regarding which medication is appropriate for their specific condition.

As of the latest available information, Onglyza (saxagliptin) has not been discontinued. It remains available as a prescription medication for the management of type 2 diabetes. However, availability can vary by region, so it is advisable to check with local pharmacies or healthcare providers for the most current information.

Onglyza is used to help control blood sugar levels in adults with type 2 diabetes. It is typically used in conjunction with diet and exercise to improve glycemic control.

Onglyza (saxagliptin) is not typically associated with weight gain. In fact, it is generally considered weight-neutral, meaning it does not significantly affect a person's weight. However, individual responses to medication can vary, and any concerns about weight changes should be discussed with a healthcare provider.

As of the latest information available, there have been no widespread announcements regarding the discontinuation of any major diabetic medications. However, availability can vary by region and manufacturer decisions. It is advisable for individuals to consult with their healthcare provider or pharmacist for the most current information regarding specific medications they are using.