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This medication comes with important safety warnings to ensure its proper use and to minimize health risks. Please read the following information carefully and discuss any concerns with your healthcare provider.

• Infections: Never share Levemir (insulin detemir) pens, syringes, or needles with others to avoid the risk of serious infections.

• Low Blood Sugar: Insulin, including Levemir, can cause low blood sugar, which may become life-threatening. Symptoms include shakiness, anxiety, confusion, or hunger. Always carry glucose tablets or fast-acting sugars to manage episodes and follow the "15-15 Rule" if necessary. Consult your doctor if you frequently experience low blood sugar, as your insulin dose may need adjustment. Factors increasing risk include changes in diet and exercise, alcohol consumption, other blood sugar medications, age over 65, and liver or kidney issues.

• Severe Allergic Reactions: Rarely, Levemir can cause severe allergic reactions. Seek emergency medical help if you experience difficulty breathing, a rapid heartbeat, or swelling of the face, mouth, or throat.

• Low Blood Potassium Levels: Levemir may decrease potassium in the blood, particularly if you are on medications that lower potassium. Your doctor will monitor your levels and may prescribe supplements if necessary. Symptoms include muscle weakness, fatigue, fast heartbeat, and tingling in extremities.

• Fluid Retention and Heart Failure Risk: If taking thiazolidinediones (TZD) along with Levemir, inform your provider as this combination can lead to fluid retention and potentially worsen heart failure. Symptoms to watch for include sudden weight gain, breathing difficulties, and fatigue. Your healthcare provider may need to adjust your medication.

Contraindications:

• Do not use this medication if you have untreated low blood sugar, as it may lead to severe health complications. Always consult your healthcare provider before starting Levemir if you have this condition.

When taking this medication, some common side effects might occur, but they are generally mild and manageable. You might experience shakiness, hunger, or other symptoms related to low blood sugar, which can be quite common. Additionally, some people may experience symptoms akin to the common cold, such as a sore throat, headache, or back pain. Flu-like symptoms such as fever and chills, along with stomach pain, are also reported occasionally. If these symptoms persist or worsen, consulting a healthcare provider is advisable.

Some individuals may notice weight gain, swelling in the hands or feet, and reactions at the injection site, including redness, pain, or itching. While these effects can be uncomfortable, they are typically not severe. However, if they become bothersome, seeking medical advice is recommended.

There are also some serious side effects to be aware of, which are rare but require prompt medical attention. Severe low blood sugar, or hypoglycemia, can manifest as shakiness, anxiety, a rapid heartbeat, or confusion. Serious allergic reactions may present with hives, swelling of the face or tongue, and breathing difficulties. Another critical condition is dangerously low potassium levels, which might cause muscle cramps, abnormal heart rhythms, or fatigue. If you experience any of these symptoms, it's crucial to seek immediate medical care.

Remember, while this list covers many potential side effects, it is not exhaustive. If you notice any other unusual effects, it's important to contact your healthcare provider.

Levemir (insulin detemir) can interact with various medications, which may affect how it works or increase the risk of side effects. It's important to inform your doctor and pharmacist about all medications, including prescription, over-the-counter, and supplements, that you are currently taking. Here are some key interactions:

1. Medications usually not recommended with Levemir: Some drugs should generally not be used with Levemir unless absolutely necessary. If prescribed together, your doctor might need to adjust the dosage or frequency. These include antibiotics like Ciprofloxacin and Levofloxacin, other medications like Chloroquine, and hormonal treatments such as Liraglutide.

2. Medications that may increase side effects: Using Levemir with certain drugs might raise the likelihood of side effects, yet sometimes this combination is required for optimal treatment. Your doctor may modify how much or how often you use one or both medicines. This group includes beta-blockers like Metoprolol and Propranolol, and other medications such as Dulaglutide and Linezolid.

For those on beta-blockers (like Metoprolol, Propranolol, or eye drops containing Timolol), it's crucial to note that these may mask symptoms of low blood sugar (hypoglycemia), such as a rapid or pounding heartbeat. However, other hypoglycemia symptoms, like dizziness, hunger, or sweating, are not affected. Regular monitoring of blood sugar levels is essential, and any changes in symptoms or blood sugar readings should be discussed with your doctor. They might need to adjust your diabetes medication, exercise regimen, or diet accordingly. Always consult with your healthcare provider before making any changes to your medication.