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Here is a comprehensive overview of essential safety information and warnings related to the use of NovoLog Mix 70/30. This information is crucial for ensuring the safe and effective use of the medication. Please consult your healthcare provider if you have any questions or concerns.

• Do Not Share Equipment: Never share your NovoLog Mix 70/30 pens, syringes, or needles with others. Sharing can lead to the transmission of severe diseases and infections.

• Risk of Low Blood Sugar (Hypoglycemia): Using NovoLog Mix 70/30, either alone or with other diabetes medications, may cause hypoglycemia, which can be life-threatening. Symptoms may include shakiness, nervousness, rapid heartbeat, sweating, confusion, drowsiness, weakness, and excessive hunger. These symptoms can occur suddenly and vary between individuals. Always carry a sugar source to manage sudden symptoms, and consult your healthcare provider about your dosage if low blood sugar is frequent. Risk factors include dietary and exercise changes, alcohol consumption, use of other diabetes medications, being aged 65 or older, and having liver or kidney issues. Correct injection technique is also crucial.

• Severe Allergic Reactions: Although rare, NovoLog Mix 70/30 can trigger severe allergic reactions that may be life-threatening. Seek immediate medical attention if you experience breathing difficulties, a blistering skin rash with fever, or swelling of the face, mouth, or throat.

• Low Blood Potassium Levels: This medication may lower your potassium levels, which is dangerous. You are at higher risk if you take medications that decrease potassium, such as laxatives or diuretics. Your healthcare provider will monitor your potassium levels and may prescribe treatments to maintain normal levels.

• Interactions with Thiazolidinediones: If you are taking thiazolidinediones, such as pioglitazone or rosiglitazone, your healthcare provider will closely monitor you. Combining these drugs with insulin can cause fluid retention, potentially leading to or exacerbating heart failure.

Please ensure you follow these safety instructions closely and discuss any concerns with your healthcare provider to maintain optimal health while using NovoLog Mix 70/30.

Common side effects:

• Low blood sugar levels
• Headaches
• Flu-like symptoms
• Weight gain
• Reactions at the injection site (skin irritation, itching, rash, or skin thickening)
• Symptoms akin to a cold

Serious side effects:

• Significant digestive issues (indigestion)
• Back pain
• Diarrhea
• Sore throat
• Allergic reactions
• Bone pain
• Severe cold-like symptoms

When using NovoLog Mix 70/30, it's important to be aware of potential interactions with other medications and substances that can affect blood sugar levels. Some drugs may increase the risk of low blood sugar (hypoglycemia), while others might reduce the effectiveness of insulin, leading to high blood sugar (hyperglycemia). Additionally, certain substances can mask the symptoms of hypoglycemia, making it harder to recognize and treat.

Medications That May Increase the Risk of Hypoglycemia:

• Antidiabetic agents: Other medications used to lower blood sugar can enhance the effect of insulin.
• ACE inhibitors and angiotensin II receptor blockers: Commonly prescribed for high blood pressure, these can increase insulin sensitivity.
• Certain heart medications: Such as disopyramide.
• Cholesterol-lowering drugs: Like fibrates.
• Antidepressants: Including Fluoxetine and monoamine oxidase inhibitors.
• Other medications: Such as Pentoxifylline, pramlintide, salicylates (like Aspirin), somatostatin analogs (e.g., Octreotide), and sulfonamide antibiotics.

Medications That May Decrease the Effectiveness of NovoLog Mix 70/30:

• Atypical antipsychotics: Such as Olanzapine and Clozapine.
• Corticosteroids: Often used to reduce inflammation.
• Hormonal therapies: Including estrogens, progestogens (found in some oral contraceptives), and thyroid hormones.
• Other medications: Such as Danazol, diuretics, glucagon, Isoniazid, Niacin, phenothiazines, protease inhibitors, somatropin, and sympathomimetic agents (e.g., Albuterol, Epinephrine, Terbutaline).

Substances That May Either Increase or Decrease Blood Sugar Levels:

• Alcohol: Can unpredictably affect blood sugar, sometimes causing it to drop too low or rise too high.
• Beta-blockers: Used for heart conditions and high blood pressure, they can mask the symptoms of low blood sugar.
• Clonidine and lithium salts: May have variable effects on blood sugar levels.
• Pentamidine: An antimicrobial that can cause low blood sugar, sometimes followed by high blood sugar.

Substances That May Mask Hypoglycemia Symptoms:

• Beta-blockers, clonidine, guanethidine, and reserpine: These can make it harder to recognize the signs of low blood sugar, such as rapid heartbeat or tremors.

Lifestyle Considerations:

• Alcohol Consumption: Drinking alcohol while using NovoLog Mix 70/30 can increase the risk of hypoglycemia. It's advisable to avoid or limit alcohol intake and monitor blood sugar levels closely if you choose to drink.
• Smoking: Tobacco use can affect insulin sensitivity and blood sugar control. Quitting smoking may require adjustments to your insulin dosage.

Always inform your healthcare provider about all medications, supplements, and lifestyle habits to ensure safe and effective use of NovoLog Mix 70/30. Regular monitoring of blood sugar levels and open communication with your healthcare team are essential for managing diabetes effectively.