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Levomefolate calcium is the calcium salt form of L-methylfolate, which is the biologically active form of folate, a B-vitamin. It is used in the body for various functions, including DNA synthesis and repair, and is often included in supplements and medications to help manage conditions related to folate deficiency.

Levomefolate calcium and methylfolate are related but not exactly the same. Levomefolate calcium is the calcium salt form of L-methylfolate, which is the biologically active form of folate. Methylfolate generally refers to L-methylfolate itself. Both are used to address folate deficiencies, but levomefolate calcium is specifically the stabilized salt form.

L-Methylfolate calcium is used as a medical food for the dietary management of individuals with conditions related to folate deficiency. It is often prescribed to support individuals with major depressive disorder who have suboptimal folate levels. Additionally, it may be used in the management of hyperhomocysteinemia and to support overall cardiovascular health.

Calcium levofolinate is used to reduce the toxic effects of methotrexate in cancer treatment, acting as a "rescue" agent. It is also used to treat folic acid deficiency and enhance the efficacy of fluorouracil in certain types of cancer therapy.

Levofolinate, also known as levoleucovorin, is a medication used to reduce the toxic effects of methotrexate, a chemotherapy drug. It is also used in combination with 5-fluorouracil to enhance its effectiveness in treating certain types of cancer. Levofolinate is a form of folinic acid, which is a derivative of folic acid.