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Amphetamine medications carry several important safety considerations that should be reviewed carefully. Below are key points regarding the potential risks, necessary precautions, and important interactions associated with their use. Always consult your healthcare provider if you have any questions or concerns.

• Misuse and Dependency Risks: Amphetamines have a potential for misuse, which can lead to addiction and serious side effects such as increased heart rate, high blood pressure, depression, and aggressive behavior. Regular long-term use may result in physical dependence and withdrawal symptoms like irritability and sleep problems upon cessation. Individuals with a history of substance or alcohol use disorder or those taking higher doses are at increased risk.

• Cardiovascular Concerns: There is a risk of serious heart issues, including sudden death, stroke, and heart attack, even when taken at normal doses. This medication can elevate heart rate and blood pressure. It’s crucial to inform your provider about any pre-existing heart conditions prior to starting treatment, and report any symptoms like fainting, chest pain, or irregular heartbeat during treatment.

• Mental Health Effects: Amphetamines may cause or exacerbate mental health issues, leading to hallucinations, aggressive behavior, or mania. These effects can occur even in individuals without a prior history of mental health disorders. Promptly consult your healthcare provider if you experience such symptoms.

• Impact on Children’s Growth: Use of amphetamines in children can result in weight loss and slowed growth. Regular monitoring of the child’s growth is necessary, and treatment may be adjusted if significant weight loss or growth delays are observed.

• Seizure Risk: Amphetamines can increase the likelihood of seizures, particularly in individuals with a history of seizures. Medical attention should be sought immediately if seizures occur, and discontinuation of the medication may be necessary.

• Raynaud's Phenomenon: This condition, characterized by reduced blood flow to the fingers and toes, may occur with amphetamine use. Symptoms include color changes, coldness, numbness, or pain in fingers and toes. These are typically mild and resolve with dose adjustments or discontinuation.

• Serotonin Syndrome: The risk for serotonin syndrome, a potentially life-threatening condition, increases when amphetamines are used with other medications affecting serotonin levels, such as certain antidepressants and migraine medications. Watch for symptoms like fast heart rate, sweating, and confusion, and seek immediate medical attention if they occur.

• Vision Problems: Some individuals may experience blurred vision or other visual disturbances. Any changes in vision should be reported to your healthcare provider.

Contraindications: Amphetamine should not be used if you have certain heart conditions, moderate-to-severe high blood pressure, overactive thyroid, agitation, a history of drug misuse, or if you have used a monoamine oxidase inhibitor (MAOI) in the past 14 days. Always consult your healthcare provider if you have any of these conditions before taking amphetamines.

These guidelines are vital for ensuring the safe and effective use of amphetamines. Your healthcare provider can offer personalized advice and support based on your specific health needs.

When taking this medication, some individuals may experience common side effects such as loss of appetite, weight loss, dry mouth, stomach upset, nausea or vomiting, dizziness, headache, diarrhea, fever, nervousness, and trouble sleeping. These effects are generally mild but should be monitored. If they persist or worsen, consulting a healthcare provider is advisable.

In some cases, more serious side effects can occur, including an increased heart rate, high blood pressure, mood or mental changes, and vision alterations. It's important to regularly check your blood pressure and report any significant changes. Additionally, some may experience changes in sexual desire or ability, restlessness, or unusual movements like twitching or teeth grinding.

Rare but severe side effects warrant immediate medical attention. These include signs of blood flow issues in extremities, prolonged or frequent erections, fainting, seizures, or symptoms resembling a heart attack or stroke, such as chest pain, shortness of breath, or sudden confusion. Serotonin syndrome is a rare condition linked to this medication, characterized by rapid heart rate, hallucinations, severe dizziness, and muscle twitching. Allergic reactions, though rare, may manifest as rashes, swelling, or breathing difficulties and require urgent care.

While this list covers many potential side effects, it's not exhaustive. If you notice any unusual or severe symptoms, contact a healthcare professional promptly.

When using this medication, keep a detailed list of all your current prescription, non-prescription, and herbal products to share with your healthcare provider. It is crucial to avoid taking monoamine oxidase inhibitors (MAOIs) such as isocarboxazid, Linezolid, Metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, Rasagiline, safinamide, Selegiline, and Tranylcypromine with this drug, as this can lead to a dangerous and potentially fatal interaction. Most MAOIs should not be taken within two weeks before starting this treatment. Consult your doctor about when to begin or discontinue this medication.

Certain products may contain ingredients that could elevate your heart rate or blood pressure. It is important to inform your pharmacist about all the products you are using to ensure safe use, especially if they include cough-and-cold products or diet aids.

Taking this medication alongside other drugs that increase serotonin levels can raise the risk of serotonin syndrome or toxicity. This risk is heightened when starting or increasing the dosage of such medications, which include street drugs like MDMA/"ecstasy," St. John's wort, and specific antidepressants such as SSRIs (e.g., Fluoxetine, paroxetine) and SNRIs (e.g., Duloxetine, Venlafaxine).

Additionally, amphetamine is closely related to Dextroamphetamine and Lisdexamfetamine, so avoid using medications that contain these substances while on amphetamine.

Lastly, this medication might interfere with certain medical or laboratory tests (like blood and urine steroid levels, and brain scans for Parkinson's disease), potentially leading to inaccurate results. Ensure that all your healthcare providers and lab personnel are aware that you are taking this medication.