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Naproxen, a nonsteroidal anti-inflammatory drug (NSAID), requires careful consideration due to its potential risks and side effects. Below are important safety guidelines and warnings to help ensure its safe use:

• Heart Attack and Stroke Risk: Naproxen may increase the likelihood of blood clots, leading to heart attacks or strokes. This risk is higher with prolonged use, higher doses, and in individuals with pre-existing heart conditions. Avoid using naproxen immediately before or after heart surgery like CABG. If you have heart-related concerns, discuss them with your healthcare provider (HCP) before starting this medication. Seek immediate medical help if you experience chest pain, shortness of breath, or sudden weakness on one side of the body.

• Stomach Bleeding: Naproxen can elevate the risk for stomach ulcers and bleeding, which can occur without warning at any time during treatment. Older adults, those with a history of stomach issues, or individuals taking certain other medications may be at greater risk. Notify your HCP about all medications and conditions before starting naproxen. Seek medical attention if you experience severe stomach pain, vomiting blood, or dark, tarry stools.

• High Blood Pressure and Heart Failure: This medication can cause fluid retention, increasing blood pressure and potentially leading to heart failure. Those with a history of heart issues or who are on blood pressure medication should consult their HCP prior to use. Be aware of symptoms like unexplained fainting or chest pain during physical activity and contact your HCP if they occur.

• Kidney Damage: Naproxen may impair kidney function, especially in older adults or those with pre-existing health conditions such as diabetes. Regular monitoring of kidney health via lab tests may be necessary. Report any changes in urination, fatigue, or muscle cramps to your HCP.

• Liver Problems: Though rare, naproxen can cause liver damage. Discontinue use and seek medical help if you notice symptoms like stomach swelling, yellowing of the skin or eyes, or dark urine.

• Severe Allergic Reactions: Allergic reactions, including anaphylaxis, can occur. Individuals with aspirin or NSAID allergies should inform their HCP before use. Immediate medical help is necessary if you experience hives, facial swelling, or difficulty breathing.

• Pregnancy and Breastfeeding: Naproxen can harm an unborn baby, especially if taken after the 20th week of pregnancy. Discuss risks and alternatives with your HCP if you are pregnant or breastfeeding.

• Contraindications: Do not use naproxen if you have a history of asthma or allergic reactions to aspirin or other NSAIDs, or if you are undergoing or have recently had heart surgery.

Consult your healthcare provider to discuss the benefits and any potential risks associated with naproxen to ensure it is the right choice for you.

When taking this medication, some common side effects may occur, but they're generally mild and temporary. These include upset stomach, nausea, heartburn, headache, drowsiness, dizziness, itchy skin, and swelling. If these persist or worsen, it's advisable to consult a healthcare provider for guidance. Additionally, some individuals might experience constipation, stomach pain, indigestion, diarrhea, sweating, mouth sores, or increased thirst.

There are more serious side effects that, although rare, require immediate medical attention. These include signs of liver damage such as persistent nausea or vomiting, loss of appetite, dark urine, abdominal pain, or yellowing of the skin or eyes. Symptoms of a severe allergic reaction, like fever, swollen lymph nodes, rash, severe dizziness, or difficulty breathing, also warrant urgent care. Other severe side effects include symptoms indicative of stomach bleeding, heart attack, stroke, heart failure, or kidney problems, such as unusual tiredness, swelling, changes in urine, or chest pain.

This medication may also cause high blood pressure, so regular monitoring is suggested, and any significant changes should be reported to a healthcare provider. While serious side effects are not common, being aware of them can help ensure timely medical intervention if needed. Always communicate with a healthcare professional if you notice any unusual or concerning symptoms.

Naproxen may interact with various medications, so it's important to inform your doctor and pharmacist about all the medications and supplements you're currently taking, including both prescription and over-the-counter options. Here are some important points to consider:

1. Medications to Avoid: Naproxen should not be used with ketorolac, as these drugs can significantly increase the risk of harmful effects.

2. Medications Typically Not Recommended: While generally not advised, certain drugs may still be prescribed with naproxen in specific cases. Your doctor might adjust dosages if necessary. These include medications like abciximab, aspirin, clopidogrel, enoxaparin, warfarin, and a variety of other anti-inflammatory and blood-thinning agents.

3. Potential for Increased Side Effects: Combining naproxen with medications such as certain blood pressure drugs (ACE inhibitors and angiotensin II receptor blockers) can increase side effects. Your doctor might adjust your treatment plan accordingly.

4. Bleeding Risk: Naproxen can heighten the risk of bleeding, especially when used with anti-platelet drugs, anticoagulants, and other similar medications.

5. Pain Relievers and Fever Reducers: Many over-the-counter products contain pain relievers such as aspirin or NSAIDs like ibuprofen, which could lead to increased side effects if used with naproxen. However, low-dose aspirin prescribed for heart attack or stroke prevention should be continued unless advised otherwise by your doctor, as naproxen might reduce aspirin’s protective effects. Discuss alternatives for pain or fever management with your healthcare provider.

6. Lab Interference: Naproxen may affect certain lab tests, potentially leading to inaccurate results. Ensure all healthcare providers and lab personnel are aware if you're taking naproxen.

Always have a discussion with your healthcare provider to understand the risks and benefits of combining these medications with naproxen.