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This medication comes with important safety warnings that outline potential risks. Review the information carefully and speak with your healthcare provider if you have any concerns.

• Persistent or Recurrent Symptoms: Heartburn, GERD, and other gastrointestinal complaints may sometimes signal serious stomach issues, including cancer. Medications like nizatidine might mask these symptoms. If your stomach issues persist despite taking nizatidine, or if they rapidly reappear after discontinuation, consult your healthcare provider. Further testing may be necessary to rule out more serious conditions.

• Increased Risk for Individuals with Kidney Impairments: Nizatidine is eliminated through urine, and those with kidney problems may experience an accumulation of the medication, leading to heightened side effects. This risk is greater in older adults with compromised kidney function. Your healthcare provider may need to monitor your kidney function regularly to ensure you are receiving an appropriate dosage. Populations at Risk: Older adults, Individuals with a history of kidney problems.

Contraindications:

• Do not use this medication if you have a severe allergy to other H2 blockers, as it may pose significant health risks. If this applies to you, consult your healthcare provider before taking this medication.

Common side effects:

• Headache
• Runny nose
• Stomach pain
• Diarrhea
• Dizziness
• Nausea
• Passing gas

Less common but important to monitor:

• Pain
• Vomiting
• Constipation
• Trouble sleeping
• Weakness
• Infection
• Fever
• Dry mouth
• Abnormal dreams
• Loss of appetite
• Sleepiness
• Cough
• Rash
• Itchiness

Serious side effects:

• Severe allergic reaction (rash, swelling of face or throat, trouble breathing)
• Persistent nausea or vomiting
• Yellowing of the skin or eyes
• Dark urine
• Confusion
• Breast swelling or soreness in males
• Easy bruising or bleeding
• Signs of infection
• Fast or pounding heartbeat
• Unusual tiredness

Nizatidine can interact with a variety of medications, which may affect their effectiveness or increase the risk of side effects. This medication reduces stomach acid, which can alter how well certain drugs are absorbed by the body. Some examples of these drugs include Atazanavir, dasatinib, some azole antifungals like Itraconazole and Ketoconazole, levoketoconazole, Pazopanib, and sparsentan. It is important to avoid taking nizatidine with other products that contain nizatidine or other H2 blockers, such as Cimetidine, Famotidine, and ranitidine.

Additionally, nizatidine may interfere with certain laboratory tests, such as urine protein tests, potentially leading to incorrect results. Make sure to inform your healthcare providers and lab personnel that you are using this medication.

Certain medications should not be used together with nizatidine, as they may cause serious interactions. These include bepridil, cisapride, Dofetilide, dronedarone, mesoridazine, Pimozide, piperaquine, saquinavir, sparfloxacin, terfenadine, Thioridazine, and Ziprasidone. In some cases, it may be necessary to use nizatidine with other medications, but your doctor might need to adjust the dosage or frequency of use. Always inform your doctor and pharmacist about all the medications and supplements you are taking, whether they are prescribed, over-the-counter, vitamins, or herbal supplements.