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The safety information and warnings below are crucial for anyone considering the use of ziprasidone (Geodon). Carefully review these points and discuss them with your healthcare provider if you have any questions or concerns.

• Increased Risk of Death in Older Adults with Dementia-Related Psychosis: Ziprasidone (Geodon) should not be used to treat dementia-related psychosis in individuals over 65, as it may increase the risk of death, often associated with strokes, vascular issues, or infections. Inform your healthcare provider if you or a loved one has dementia before starting this medication.

• Suicidal Thoughts and Behaviors: Individuals with schizophrenia or bipolar I disorder may have an increased risk of self-harm or suicidal thoughts. Seek immediate medical attention if you experience such thoughts.

• Uncontrolled Muscle Movements (Tardive Dyskinesia): This medication may cause irreversible muscle movements, particularly in older adults, females, or those taking high doses or using the drug long-term. Discontinue use and consult your provider if you notice involuntary movements.

• Metabolic Changes: Ziprasidone (Geodon) can elevate blood sugar, cholesterol levels, and appetite, potentially leading to weight gain. Regular blood tests may be necessary, and maintaining a healthy diet and exercise routine is advised.

• Neuroleptic Malignant Syndrome: A rare but serious condition that includes symptoms like fever, muscle stiffness, and irregular heartbeat. If you experience these symptoms, seek immediate medical attention.

• Drowsiness and Cognitive Impairment: The medication can cause sleepiness and impair concentration, especially when combined with other sedative drugs. Avoid driving or operating machinery until you understand how it affects you.

• Blood Pressure Changes and Fall Risk: Ziprasidone (Geodon) may lower blood pressure causing dizziness or falls. Stand up slowly from sitting or lying positions and inform your provider if you experience falls.

• Infection Risk from Low White Blood Cell Count: The medication can reduce white blood cells, increasing infection risk. Regular blood tests may be necessary, and any signs of infection should prompt immediate medical consultation.

• Seizure Risk: Inform your provider if you have a history of seizures or conditions that increase seizure risk before starting the medication.

• Serious Skin Reactions: Rare skin reactions, including SJS and DRESS, may occur. Notify your provider immediately if you experience symptoms like rash, fever, or blistering skin.

• Prolonged and Painful Erection: Though rare, this condition requires urgent medical attention if an erection lasts beyond 4 hours.

• Elevated Prolactin Levels: Ziprasidone (Geodon) can increase prolactin, causing symptoms like nipple discharge, enlarged breasts, or menstrual irregularities. Discuss any concerns with your provider.

• Heart Rhythm Issues: The medication can affect heart rhythm, particularly if combined with other similar drugs or in individuals with existing heart conditions. Heart monitoring and electrolyte testing may be required.

Contraindications: Avoid using ziprasidone (Geodon) if you have heart rhythm problems (QT prolongation), are on medications affecting heart rhythm, or have had a recent heart attack or uncontrolled heart failure. Always consult your healthcare provider if any of these conditions apply to you.

Common side effects:

• Uncontrolled body movements
• Sleepiness
• Nausea
• Constipation
• Indigestion
• Restlessness
• Dizziness
• Respiratory tract infections

Less common but important to monitor:

• Weakness
• Chest pain
• Racing heart
• Diarrhea
• Dry mouth
• Reduced appetite
• Runny nose
• Cough
• Rash
• Changes in vision

Serious side effects:

• Suicidal thoughts and behavior
• Seizures
• Difficulty swallowing
• Tardive dyskinesia
• Neuroleptic malignant syndrome
• Stroke
• High blood sugar
• Serious infections
• Severe skin reactions

Interactions with high risk of serious adverse effects and should be avoided:

• MAO inhibitors (isocarboxazid, Linezolid, Metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, Rasagiline, safinamide, Selegiline, Tranylcypromine) - risk of serious, possibly fatal, interaction.

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Drugs that increase serotonin (MDMA, St. John's wort, SSRIs such as Fluoxetine/paroxetine, SNRIs such as Duloxetine/Venlafaxine) - risk of serotonin syndrome/toxicity.
• Heart rhythm affecting drugs (Amiodarone, Dofetilide, Moxifloxacin, Pimozide, procainamide, quinidine, Sotalol, Tacrolimus, Thioridazine) - risk of QT prolongation.

Interactions with low risk that usually do not require a change in therapy:

• Dolasetron.
• Metoclopramide.
• Products that cause drowsiness (opioid pain relievers such as codeine/hydrocodone, alcohol, marijuana, sleep or anxiety drugs such as Alprazolam/Lorazepam/Zolpidem, muscle relaxants such as Carisoprodol/Cyclobenzaprine, antihistamines such as Cetirizine/diphenhydramine).