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When using oxybutynin, it is crucial to be aware of important safety information to minimize potential risks. Below are key warnings and contraindications associated with this medication. Please read them carefully and discuss any concerns with your healthcare provider.

• Swelling (Angioedema): Oxybutynin may cause angioedema, which is swelling of the face, lips, tongue, throat, or other organs. This can occur at any time and may lead to breathing difficulties in severe cases. If you experience persistent swelling in the head or neck, seek medical advice promptly.

• Mental and Physical Side Effects: This medication can lead to side effects such as confusion, drowsiness, and hallucinations, primarily within the first few months of treatment or after increasing the dose. These effects are more likely if you are on high doses, taking anticholinesterase medications for dementia, or have conditions like Parkinson's disease. Exercise caution when driving or performing tasks that require alertness until you are familiar with how oxybutynin affects you. Contact your healthcare provider if these side effects occur, as a dosage adjustment or alternative medication may be necessary.

• Exacerbation of Existing Conditions: Oxybutynin may worsen symptoms of certain medical conditions. Use this medication with caution if you have myasthenia gravis, urinary difficulties, or specific gastrointestinal issues such as ulcerative colitis or acid reflux.

• Heat Sensitivity: Oxybutynin reduces the body's ability to sweat, increasing the risk of overheating in hot weather or during physical activity. This can lead to heat exhaustion or heat stroke. Stay hydrated and avoid excessive heat exposure.

Contraindications:

• Do Not Use If You Have:
  • Difficulty urinating
  • Gastrointestinal motility disorders
  • Uncontrolled narrow-angle glaucoma

Please consult your healthcare provider before starting oxybutynin if any of these conditions apply to you. In the event of an overdose, seek emergency medical attention immediately.

Common side effects:

• Dry mouth
• Dizziness
• Constipation
• Sleepiness
• Nausea
• Blurry vision

Less common but important to monitor:

• Headaches
• Diarrhea
• Feeling of nervousness
• Difficulty urinating
• Heartburn

Serious side effects:

• Severe allergic reactions like angioedema
• Fast or pounding heartbeat
• Mental/mood changes
• Signs of a kidney infection

Interactions with high risk of serious adverse effects and should be avoided:

• Potassium

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Bupropion
• Clozapine
• Donepezil
• Glucagon
• Glycopyrrolate
• Glycopyrronium Tosylate
• Methacholine
• Quetiapine
• Revefenacin
• Scopolamine
• Secretin Human
• Tiotropium

Interactions with low risk that usually do not require a change in therapy:

• Galantamine
• Ketoconazole
• Rivastigmine