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This document outlines essential safety information regarding the use of oxybutynin, highlighting potential risks and necessary precautions. Please review the information carefully and consult your healthcare provider with any questions or concerns.

• Angioedema (Swelling of Face, Lips, Tongue): Oxybutynin may cause angioedema, which is swelling that can occur in the face, lips, tongue, throat, or other organs. This condition can develop at any time and may lead to breathing difficulties in severe cases. Seek medical advice if you experience persistent swelling in the head or neck area.

• Neurological Side Effects: The medication may lead to confusion, drowsiness, and hallucinations, particularly within the first few months of treatment or after a dosage increase. These effects are more likely if you are on high doses of oxybutynin, taking anticholinesterase drugs for dementia, or have nervous system disorders like Parkinson's disease. Exercise caution when driving or performing tasks that require alertness until you understand how the medication affects you. Contact your healthcare provider if these symptoms occur; a dosage adjustment or alternative treatment may be necessary.

• Exacerbation of Pre-existing Conditions: Oxybutynin can aggravate certain medical conditions due to its mechanism of action and side effects. Exercise caution if you have conditions such as myasthenia gravis, urinary difficulties, or gastrointestinal disorders like ulcerative colitis or acid reflux. Discuss these conditions with your healthcare provider.

• Heat Exhaustion: This medication can impair your ability to sweat and regulate body temperature, increasing the risk of overheating, especially in hot weather or during physical activity. To prevent heat exhaustion or heat stroke, stay hydrated and avoid high temperatures whenever possible.

Contraindications: Do not use oxybutynin if you have any of the following conditions without consulting your healthcare provider, as it may pose significant health risks:

• Difficulty urinating.
• Gastrointestinal movement disorders.
• Uncontrolled narrow angle glaucoma.

Please ensure you follow these guidelines and consult your healthcare provider for personalized advice related to your health condition and treatment plan.

When taking this medication, you may experience a range of side effects. Common side effects include dry mouth, dizziness, constipation, drowsiness, nausea, and blurred vision. These effects are usually mild and often manageable. To alleviate dry mouth, consider using sugarless hard candy, gum, or saliva substitutes. Drinking water and using artificial tears can help with dry eyes. Constipation can be eased by incorporating dietary fiber, staying hydrated, and engaging in regular exercise, with a laxative being an option if necessary.

In some cases, more serious side effects may occur, though they are less common. These include decreased sexual activity, difficulty urinating, fast or pounding heartbeat, and signs of a kidney infection such as burning urination or lower back pain. Other serious effects to watch for are mental or mood changes, swelling of the limbs, vision problems, seizures, or a stomach or intestinal blockage. These require prompt medical attention.

Severe allergic reactions like angioedema, which involves swelling of the face, lips, tongue, or throat, are rare but critical. If you experience symptoms such as a rash, severe dizziness, or trouble breathing, seek medical help immediately. While not all possible side effects are listed, contact your healthcare provider if you notice any new or worsening symptoms.

When taking oxybutynin, it's important to be aware of potential interactions with other medications. Inform your doctor or pharmacist about all the medications and supplements you're using, including prescriptions, over-the-counter drugs, vitamins, and herbal products. Some interactions to note are:

• Medications to Avoid: It is generally advised not to use oxybutynin with potassium supplements or potassium-containing medications, as they can irritate the esophagus or stomach.

• Caution Required: Combining oxybutynin with the following medications might not be recommended but could be necessary in some situations. If both are needed, your doctor may adjust the dosage or frequency: bupropion, Clozapine, Donepezil, glucagon, Glycopyrrolate, glycopyrronium tosylate, methacholine, Quetiapine, revefenacin, Scopolamine, secretin human, and Tiotropium.

• Increased Side Effect Risk: Taking oxybutynin with Galantamine, Ketoconazole, or Rivastigmine may heighten the risk of side effects. However, your healthcare provider might determine that using them together is beneficial and adjust dosages accordingly.

Additionally, be cautious with products that cause drowsiness, such as opioid pain relievers, alcohol, marijuana, sleep or anxiety medications, muscle relaxants, or antihistamines. Always check with your pharmacist to ensure safe use of any products that might cause drowsiness, constipation, or blurred vision.