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Oxymorphone is a potent medication with several important safety considerations to be aware of. Here is a summary of the critical safety information and warnings associated with its use:

• Risk of Abuse and Addiction: Oxymorphone is a controlled substance due to its potential for misuse and addiction. It is crucial to take the smallest effective dose and only for the shortest duration necessary. Do not alter your dosage without consulting your healthcare provider.

• Breathing Problems: This medication can cause severe respiratory depression, which may be fatal. The risk is higher at the start of treatment, after a dose increase, or when taken incorrectly. Exercise caution if you have a history of breathing problems, are elderly, or are taking other medications that can slow breathing. Always have naloxone on hand as a precaution and ensure family members know how to use it.

• Overdose Risk: Taking too much oxymorphone can lead to an overdose, which is life-threatening. Keep this medication out of reach of children and others to prevent accidental ingestion. Symptoms of overdose include extreme drowsiness, slow breathing, and unresponsiveness.

• Interactions with Other Substances: Avoid alcohol and other medications that may cause drowsiness or respiratory depression, such as benzodiazepines and muscle relaxants, as these can exacerbate side effects.

• Pregnancy and Newborn Considerations: If you are pregnant or planning to become pregnant, discuss the risks with your doctor. Prolonged use during pregnancy can lead to neonatal opioid withdrawal syndrome, which is potentially life-threatening for the newborn. Use the lowest effective dose for the shortest possible time.

• Physical Dependence and Withdrawal: Long-term use can lead to physical dependence. Do not stop taking oxymorphone suddenly to avoid withdrawal symptoms, such as anxiety and irritability. Your doctor will guide you on how to taper the dose safely if necessary.

• Allergic Reactions: Some individuals may experience severe allergic reactions, including swelling, hives, or difficulty breathing. Seek immediate medical attention if these occur.

• Blood Pressure: This medication may cause low blood pressure, leading to dizziness or fainting. Rise slowly from sitting or lying positions to reduce the risk of falls.

• Adrenal Hormone Levels: Prolonged use may lead to low adrenal hormone levels, which can cause fatigue and dizziness. Inform your healthcare provider if you experience these symptoms.

• Seizure Risk: If you have a history of seizures, be aware that oxymorphone may increase their frequency. Seek medical help immediately if you experience a seizure.

• Contraindications: Oxymorphone should not be used by individuals with severely slowed breathing, severe asthma, conditions causing stomach blockage, or moderate to severe liver disease. If any of these apply to you, consult your healthcare provider before use.

Always take oxymorphone exactly as prescribed and consult your healthcare provider with any questions or concerns to ensure safe and effective use.

Common side effects:

• nausea
• vomiting
• headache
• constipation
• dry mouth
• mild itching
• dizziness
• drowsiness

Less common but important to monitor:

• sleep apnea
• mental or mood changes
• confusion
• hallucinations
• abdominal pain
• vision changes
• irregular heartbeat
• difficulty urinating
• difficulty swallowing
• loss of appetite
• unusual tiredness

Serious side effects:

• slow or shallow breathing
• fainting
• seizures
• severe drowsiness
• allergic reactions
• rash
• significant itching or swelling
• severe dizziness
• trouble breathing

Interactions with high risk of serious adverse effects and should be avoided:

• Nalmefene
• Naltrexone
• Safinamide

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Alprazolam
• Hydrocodone
• Carisoprodol
• Cetirizine
• Alcohol
• Butorphanol
• Nalbuphine
• Pentazocine
• Samidorphan
• Codeine
• Lorazepam
• Zolpidem
• Cyclobenzaprine
• Diphenhydramine
• Opioid pain relievers
• Cough relievers
• Marijuana (cannabis)
• Drugs for sleep or anxiety
• Muscle relaxants
• Antihistamines