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Phenoxybenzamine (Dibenzyline) is a medication with specific safety warnings and precautions that must be carefully considered before and during use. It's crucial to be informed about these risks and to discuss any concerns with your healthcare provider.

• Postural Hypotension: Phenoxybenzamine can lead to a significant drop in blood pressure when standing up from a sitting or lying position. This may result in dizziness or fainting, particularly if you are also taking medications for high blood pressure or erectile dysfunction. Extra caution is advised when starting phenoxybenzamine or increasing the dose. Those with a history of low blood pressure or similar issues should be especially vigilant.

• Drug Interactions: As phenoxybenzamine lowers blood pressure by blocking alpha receptors, it may interact with medications that activate these receptors, such as epinephrine (Epipen), which is used in allergic reactions to raise blood pressure. This interaction can reduce the effectiveness of epinephrine. It's important to consult your healthcare provider or pharmacist to ensure there are no harmful interactions with your current medications before starting phenoxybenzamine.

• Long-term Use Concerns: This medication is not recommended for long-term use due to reports of cancer development in some individuals who used it over extended periods. Discuss the appropriate duration of treatment with your healthcare provider.

• Contraindications: Phenoxybenzamine should be avoided in conditions where a drop in blood pressure is undesirable. If you have any medical conditions that contraindicate the use of this medication, it is essential to speak with your healthcare provider.

In case of an overdose or adverse reaction, seek immediate medical attention. Always adhere to your healthcare provider's instructions when using phenoxybenzamine to ensure safety and efficacy.

Common side effects:

• stomach upset
• nausea
• stuffy nose
• drowsiness
• dizziness
• decrease in pupil size

Less common but important to monitor:

• fast or pounding heartbeat
• fainting
• sexual problems in males (difficulty ejaculating)
• dangerously low blood pressure

Serious side effects:

• painful or prolonged erection lasting four or more hours
• very serious allergic reactions (rash, itching, swelling, severe dizziness, trouble breathing)

Interactions with high risk of serious adverse effects and should be avoided:

• Alfuzosin
• Asenapine
• Silodosin
• Tadalafil
• Tamsulosin

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Erectile dysfunction drugs (such as sildenafil, tadalafil)
• Epinephrine
• Other alpha blockers (such as prazosin)
• Other drugs for high blood pressure (such as diuretics, ACE inhibitors, beta blockers)
• Beta-blockers (such as Acebutolol, Alprenolol, Atenolol, etc.)

Interactions with low risk that usually do not require a change in therapy:

• Opioid pain or cough relievers (such as codeine, hydrocodone)
• Alcohol
• Marijuana (cannabis)
• Drugs for sleep or anxiety (such as alprazolam, lorazepam, zolpidem)
• Muscle relaxants (such as carisoprodol, cyclobenzaprine)
• Antihistamines (such as cetirizine, diphenhydramine)
• NSAIDs (such as ibuprofen, naproxen)