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Phenoxybenzamine (Dibenzyline) is a medication with specific safety warnings and precautions that must be carefully considered before and during use. It's crucial to be informed about these risks and to discuss any concerns with your healthcare provider.

• Postural Hypotension: Phenoxybenzamine can lead to a significant drop in blood pressure when standing up from a sitting or lying position. This may result in dizziness or fainting, particularly if you are also taking medications for high blood pressure or erectile dysfunction. Extra caution is advised when starting phenoxybenzamine or increasing the dose. Those with a history of low blood pressure or similar issues should be especially vigilant.

• Drug Interactions: As phenoxybenzamine lowers blood pressure by blocking alpha receptors, it may interact with medications that activate these receptors, such as epinephrine (Epipen), which is used in allergic reactions to raise blood pressure. This interaction can reduce the effectiveness of epinephrine. It's important to consult your healthcare provider or pharmacist to ensure there are no harmful interactions with your current medications before starting phenoxybenzamine.

• Long-term Use Concerns: This medication is not recommended for long-term use due to reports of cancer development in some individuals who used it over extended periods. Discuss the appropriate duration of treatment with your healthcare provider.

• Contraindications: Phenoxybenzamine should be avoided in conditions where a drop in blood pressure is undesirable. If you have any medical conditions that contraindicate the use of this medication, it is essential to speak with your healthcare provider.

In case of an overdose or adverse reaction, seek immediate medical attention. Always adhere to your healthcare provider's instructions when using phenoxybenzamine to ensure safety and efficacy.

Common side effects:

• stomach upset
• nausea
• stuffy nose
• drowsiness
• dizziness
• decrease in pupil size

Less common but important to monitor:

• fast or pounding heartbeat
• fainting
• sexual problems in males (difficulty ejaculating)
• dangerously low blood pressure

Serious side effects:

• painful or prolonged erection lasting four or more hours
• very serious allergic reactions (rash, itching, swelling, severe dizziness, trouble breathing)

When taking Phenoxybenzamine (Dibenzyline), it's important to be aware of possible interactions with certain medications. Inform your doctor or pharmacist about all medications and supplements you are currently using, including prescription, over-the-counter, vitamins, and herbal products. The list provided here may not cover all potential interactions.

Medications to Use with Caution

There are certain medications that may not typically be recommended for use with Phenoxybenzamine; however, your doctor might decide that the combination is necessary. In such cases, your doctor may adjust the dosages or the frequency of use. These medications include Alfuzosin, Asenapine, Silodosin, Tadalafil, and Tamsulosin.

Possible Side Effect Risks

Combining Phenoxybenzamine with beta-blockers can increase the risk of side effects. However, your healthcare provider may determine that using both is the best approach for your condition. Some of these beta-blockers include Acebutolol, Alprenolol, Atenolol, Betaxolol, and others such as Carvedilol, Metoprolol, and Propranolol.

Additionally, be cautious with products that might cause drowsiness, such as opioid pain relievers, alcohol, cannabis, sleep aids, muscle relaxants, and antihistamines. Always check the labels of any cough, cold, or allergy medications, as these could contain ingredients that induce drowsiness. Some products might also contain substances that elevate blood pressure, so discuss with your pharmacist how to use these safely, particularly with cough-and-cold remedies, diet aids, or NSAIDs like Ibuprofen and Naproxen.