Phenoxybenzamine coupons
Phenoxybenzamine

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generic Dibenzyline

Phenoxybenzamine, known by the brand name Dibenzyline, is prescribed for managing high blood pressure and excessive sweating in adults with a type of adrenal gland tumor called pheochromocytoma. It is an alpha blocker that functions by relaxing and widening blood vessels, which allows blood to flow more easily and helps lower blood pressure. This also reduces sweating associated with pheochromocytoma. Typically, it is taken orally 2 to 4 times a day, but it is not intended for long-term use. Common side effects include low blood pressure when standing, fast heart rate, and nasal congestion. Phenoxybenzamine is available both as a brand-name and a more affordable generic option. Always consult your healthcare provider before starting any new medication.
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10MG, Phenoxybenzamine (30 Capsules)

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CVS

$297.81

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Walgreens

$1007.67

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$2719.36

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Phenoxybenzamine savings card

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CVS

$297.81

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Phenoxybenzamine dosage forms

The average cost for 30 Capsules of Phenoxybenzamine (generic Dibenzyline) at 10MG is $302.88 with a free coupon. This is 7.80% off the average retail price of $3883.5
DosageQuantityPrice fromPer unit
10MG30 Capsules$302.88$10.1

Phenoxybenzamine Warnings

Phenoxybenzamine (Dibenzyline) is a medication with specific safety warnings and precautions that must be carefully considered before and during use. It's crucial to be informed about these risks and to discuss any concerns with your healthcare provider.

  • Postural Hypotension: Phenoxybenzamine can lead to a significant drop in blood pressure when standing up from a sitting or lying position. This may result in dizziness or fainting, particularly if you are also taking medications for high blood pressure or erectile dysfunction. Extra caution is advised when starting phenoxybenzamine or increasing the dose. Those with a history of low blood pressure or similar issues should be especially vigilant.

  • Drug Interactions: As phenoxybenzamine lowers blood pressure by blocking alpha receptors, it may interact with medications that activate these receptors, such as epinephrine (Epipen), which is used in allergic reactions to raise blood pressure. This interaction can reduce the effectiveness of epinephrine. It's important to consult your healthcare provider or pharmacist to ensure there are no harmful interactions with your current medications before starting phenoxybenzamine.

  • Long-term Use Concerns: This medication is not recommended for long-term use due to reports of cancer development in some individuals who used it over extended periods. Discuss the appropriate duration of treatment with your healthcare provider.

  • Contraindications: Phenoxybenzamine should be avoided in conditions where a drop in blood pressure is undesirable. If you have any medical conditions that contraindicate the use of this medication, it is essential to speak with your healthcare provider.

In case of an overdose or adverse reaction, seek immediate medical attention. Always adhere to your healthcare provider's instructions when using phenoxybenzamine to ensure safety and efficacy.

Phenoxybenzamine Side Effects

Common side effects:

  • stomach upset
  • nausea
  • stuffy nose
  • drowsiness
  • dizziness
  • decrease in pupil size

Less common but important to monitor:

  • fast or pounding heartbeat
  • fainting
  • sexual problems in males (difficulty ejaculating)
  • dangerously low blood pressure

Serious side effects:

  • painful or prolonged erection lasting four or more hours
  • very serious allergic reactions (rash, itching, swelling, severe dizziness, trouble breathing)

Phenoxybenzamine Interactions

Interactions with high risk of serious adverse effects and should be avoided:

  • Alfuzosin
  • Asenapine
  • Silodosin
  • Tadalafil
  • Tamsulosin

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

  • Erectile dysfunction drugs (such as sildenafil, tadalafil)
  • Epinephrine
  • Other alpha blockers (such as prazosin)
  • Other drugs for high blood pressure (such as diuretics, ACE inhibitors, beta blockers)
  • Beta-blockers (such as Acebutolol, Alprenolol, Atenolol, etc.)

Interactions with low risk that usually do not require a change in therapy:

  • Opioid pain or cough relievers (such as codeine, hydrocodone)
  • Alcohol
  • Marijuana (cannabis)
  • Drugs for sleep or anxiety (such as alprazolam, lorazepam, zolpidem)
  • Muscle relaxants (such as carisoprodol, cyclobenzaprine)
  • Antihistamines (such as cetirizine, diphenhydramine)
  • NSAIDs (such as ibuprofen, naproxen)
Phenoxybenzamine FAQs
Is phenoxybenzamine an alpha-1 blocker?

Phenoxybenzamine is a non-selective alpha-adrenergic blocker, meaning it blocks both alpha-1 and alpha-2 adrenergic receptors.

Phenoxybenzamine is used to treat high blood pressure and sweating associated with pheochromocytoma, a type of tumor that can increase the production of certain hormones. It is an alpha-adrenergic blocker that helps manage symptoms by relaxing blood vessels and reducing blood pressure.

Phenoxybenzamine is given for pheochromocytoma to manage hypertension and prevent hypertensive crises. It is a non-selective alpha-adrenergic antagonist that helps to block the effects of excess catecholamines produced by the tumor, thereby reducing blood pressure and alleviating symptoms associated with the condition.

The gold standard treatment for pheochromocytoma is surgical removal of the tumor, typically through an adrenalectomy. Prior to surgery, patients are usually treated with alpha-adrenergic blockers to control hypertension and prevent intraoperative complications.

Phenoxybenzamine may cause several side effects. Common side effects include dizziness, drowsiness, fatigue, and nasal congestion. It can also cause orthostatic hypotension, which is a drop in blood pressure upon standing, leading to lightheadedness or fainting. Other possible side effects include tachycardia (increased heart rate), gastrointestinal disturbances such as nausea or vomiting, and sexual dysfunction. It is important for individuals to discuss any side effects they experience with their healthcare provider.