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When using this medication, it is important to be aware of the potential for serious side effects, particularly in older adults with dementia. These side effects can include stroke, heart failure, irregular heartbeat, and pneumonia, some of which could be fatal. It is crucial to note that this medication is not approved to manage behavior problems associated with dementia.

• Discuss the potential risks and benefits of this medication with your doctor, especially if considering other effective and possibly safer treatments for behavior issues related to dementia.
• If you are taking asenapine alongside other medications for depression, ensure you review the safety information for the additional medication carefully.

Always consult with a healthcare professional before making changes to your medication regimen.

When taking this medication, you might experience drowsiness, dizziness, lightheadedness, or weight gain. It's also common to feel numbness or tingling around the mouth, which usually fades within an hour. In rare instances, sores or blisters might appear under the tongue. If these symptoms persist or worsen, it's important to seek medical advice.

Dizziness and lightheadedness can increase the risk of falls, so it's wise to rise slowly from sitting or lying down. Contact your healthcare provider promptly if you experience muscle stiffness, tremors, restlessness, facial stiffness, drooling, trouble swallowing, or a shuffling walk, as these may require additional medication to manage.

Uncommon but serious side effects include involuntary movements such as lip smacking or tongue thrusting, which could indicate a condition called tardive dyskinesia. In rare cases, this medication may affect blood sugar levels, heightening the risk of diabetes, so monitor any increased thirst or urination closely. For those with diabetes, regular blood sugar checks are crucial.

The drug might also raise prolactin levels, potentially causing unwanted breast milk, menstrual changes, or fertility issues in females, and decreased sexual function or breast enlargement in males. Rarely, males might experience a prolonged, painful erection lasting over four hours, requiring immediate medical attention.

Be alert for serious side effects like sleep apnea, persistent fever, or signs of infection. Rarely, a severe condition called neuroleptic malignant syndrome (NMS) may occur, characterized by symptoms like fever, muscle pain, and confusion. Seek urgent medical help for severe dizziness, fainting, slow heartbeat, seizures, or allergic reactions such as rash, swelling, or breathing difficulty. If you experience any other unusual effects, consult your healthcare provider.