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When considering the use of asenapine (Saphris), it is crucial to be aware of the associated safety information and warnings. This medication can pose several risks, and understanding them will help you make informed decisions about your treatment. Below are key points to consider:

• Increased Risk in Older Adults with Dementia: Asenapine is not approved for treating dementia-related psychosis and is linked to a higher risk of death in individuals over 65 with dementia. Causes of death are often related to heart issues or infections. Discuss alternative treatment options with your doctor.

• Neuroleptic Malignant Syndrome (NMS): This rare but life-threatening condition is associated with antipsychotics. Symptoms include high fever, rapid heartbeat, muscle stiffness, and confusion. Immediate medical attention is necessary if these symptoms occur.

• Movement Disorders: Long-term use may lead to tardive dyskinesia (TD), causing involuntary movements such as lip smacking and eye blinking. This condition can be permanent. To minimize risk, your doctor will prescribe the lowest effective dose and regularly assess your need for the medication.

• Metabolic Changes: Asenapine can lead to high blood sugar, high cholesterol, and weight gain, increasing the risk of heart disease and stroke. Discuss preventive strategies with your healthcare provider.

• Allergic Reactions: Rare but serious allergic reactions can occur. Seek medical help if you experience symptoms like rash, rapid heartbeat, swelling, or breathing difficulties.

• Blood Pressure and Heartbeat Changes: Asenapine can cause low blood pressure and changes in heartbeat, especially when transitioning from sitting or lying down. If you have a history of heart issues, inform your prescriber.

• White Blood Cell Count: This medication can lower white blood cell levels, increasing infection risk. Monitor for fever or frequent illnesses and inform your doctor. Blood tests may be necessary during treatment.

• Seizures: There's an increased risk of seizures, particularly if you have a history of seizures or related health conditions. Discuss these risks with your prescriber.

• High Prolactin Levels: Prolonged use can raise prolactin hormone levels, leading to menstrual changes, fertility issues, and mood or sexual problems. Consult your healthcare team if concerned.

• Phenylketonuria (PKU): Some tablets contain phenylalanine, which can be harmful to individuals with PKU. Inform your doctor if you have this condition.

• Contraindications: Severe liver problems are a contraindication for asenapine use. Always inform your healthcare provider of any liver issues before starting this medication.

It is essential to discuss these risks and any other concerns with your healthcare provider to ensure that asenapine is a safe and appropriate choice for your treatment.

Common side effects:

• Drowsiness
• Dizziness
• Lightheadedness
• Weight gain
• Trouble sleeping
• Mouth numbness
• Movement issues
• Restlessness
• Constipation
• Vomiting
• Dry mouth
• Increased salivation
• Tiredness
• Irritability
• Bigger appetite
• Stomach discomfort

Serious side effects:

• Depression or thoughts of self-harm
• Seizures
• Neuroleptic malignant syndrome
• Serious allergic reaction
• Changes in heartbeat
• High blood pressure
• Tardive dyskinesia
• Diabetes
• Unwanted breast milk or menstrual changes
• Decreased sexual ability or enlarged breasts
• Interrupted breathing during sleep
• Signs of infection
• Painful, prolonged erection

Interactions with high risk of serious adverse effects and should be avoided:

• Bepridil
• Bromopride
• Cisapride
• Dronedarone
• Mesoridazine
• Metoclopramide
• Pimozide
• Piperaquine
• Saquinavir
• Sparfloxacin
• Terfenadine
• Thioridazine
• Ziprasidone

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Paroxetine
• Alprazolam
• Amiodarone
• Buprenorphine
• Codeine
• Cyclobenzaprine